T-bet对免疫细胞分化的调节及其与自身免疫病的关系

Transcription factor T-bet in immunocyte and autoimmune diseases

T盒转录因子T-bet是Th1型免疫的关键调节因子,在T淋巴细胞、B淋巴细胞、树突状细胞、NK细胞效应细胞的建立和维持中发挥着极其重要的作用,一些自身免疫病,特别是典型的与Th1免疫相关的疾病,其发病需要T-bet参与,这些在动物模型中得到证实。在此,就T-bet在免疫细胞分化和自身免疫病发病机制中的作用及其在干预治疗中的可行性做一综述。

Transcription factor T-bet has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases,especially those classically considered related to T helper 1 （Th1） immunity, appear to require T-bet, at least as judged in mouse models. This review summarizes a current understanding of T-bet＇ s role in immunity, as well as its importance in autoimmunity, with implications for therapeutic intervention.