新型大环席夫碱化合物的合成及其抗菌活性研究

Synthesis and Antibacterial Activity of Novel Schiff Base Macrocyclic Compounds

利用Ca2+,Ba2+离子作为模板离子,由2,4-二羟基-5-乙酰苯乙酮与烷基二胺[即1,3-丙二胺,1,4-丁二胺,1,6-己二胺]反应,分别合成了系列新型席夫碱大环化合物Ln(n=3,4,6).对合成得到的新型大环席夫碱化合物采用元素分析,1HNMR,IR,紫外-可见光谱和MS等进行组成和结构表征,体外抗菌活性也被试验.

Using Ca^2＋ or Ba^2＋ as the template 2,4-dihydroxy-5-acetylacetophenone was reacted with a series of diamine to yield novel macrocyclic Schiff base compounds （Ln）. Their structures were characterized by elemental analysis, ^1H NMR, IR, UV-vis and MS techniques, and the in vitro antimicrobial activities were also tested.