甲襞微循环在系统性硬化症中的临床意义及特点

Clinical significance and features of nail fold microcirculation in systemic sclerosis patients

目的:观察甲襞微循环在系统性硬化症(systemic sclerosis,SSc)中的意义及特点。方法:选取2000-2007年在我院风湿科住院的SSc或其他结缔组织病的患者,所有患者均伴有雷诺现象,并行甲襞微循环检查,比较SSc患者与其他结缔组织病患者之间的甲襞微循环的各项指标,并分析甲襞微循环的异常程度对SSc的诊断是否有意义。结果:SSc组的总积分显著高于对照组,且通过Logistic回归分析,发现IgG、Scl-70及甲襞微循环的异常程度与SSc的诊断相关。结论:甲襞微循环的不同积分,可以为区分系统性硬化症与其他结缔组织病提供有力的依据,可作为对有转化为SSc可能的患者的早期诊断工具。

Objective： To study the clinical significance and features of nail fold microcirculation in patients with systemic sclerosis. Methods： Patients with Ranaud＇s phenomenon were observed and their nail fold microcirculation was examined in our hospital from 2001 to 2007. Their abnormal degree of nail fold microcirculation and clinical symptoms were compared. Results： Nail fold microcirculation in SSc patients was more abnormal than that in other connective tissue disease patients, and IgG, Scl-70 and nail fold microcirculation were related to diagnosis SSc through logistic analysis. Conclusion： Different calculus of nail fold microcirculation could distinguish between SSc and other connective tissue diseases, and therefore it could serve as an instrument for the diagnosis of early SSc.