类风湿关节炎血清葡萄糖-6-磷酸异构酶治疗前后变化特点

Change of glucose-6-phosphate isomerase in the rheumatoid arthritis before and after therapy

目的:通过测定葡萄糖-6-磷酸异构酶(GPI)在类风湿关节炎(RA)治疗前后的变化,分析GPI对RA疗效判断的意义。方法:检测RA组、健康对照组血清的GPI、类风湿因子(RF)浓度,并对结果进行统计分析。结果:RA组的GPI浓度值和阳性率均显著高于健康对照组(P<0.001),且RA活动组GPI浓度值和阳性率显著高于RA非活动组(P<0.001);治疗后随病情缓解,GPI浓度值显著下降。结论:GPI在RA中的升高程度与关节炎的活动性有关,并随病情缓解下降,可作为治疗后病情缓解的指标。

Objective： To investigate the relationship between glucose-6-phosphate isomerase （GPI） and therapeutic effect in patients with rheumatoid arthritis by measuring the level of serum GPI before and after the therapy. Methods： The serum levels of GPI and RF in 51 rheumatoid arthritis patients and in 30 healthy controls were tested and analyzed before and after the therapy. Results： The serum level of GPI and positive rates of RF in RA patients were significantly higher than those in healthy controls （P 〈 0. 001 ）; and those in active rheumatoid arthritis group were significantly higher than those in non-active group （P〈0.001）. When the disease was controlled after the therapy, the serum level of GPI decreased significantly. Conclusion： The increased GPI level in RA patients is related to the activity of arthritis. Serum level of GPI could be recognized as an indicator of RA remission after treatment.