慢性心力衰竭患者血浆VWF、P-选择素、PAI-1水平变化及其临床意义被引量：1

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摘要目的观察慢性心力衰竭(CHF)患者内皮细胞、血小板功能及纤溶活性变化,探讨其临床意义。方法测定48例CHF患者血浆血管性血友病因子(VWF)、P-选择素、纤溶酶原激活物抑制因子-1(PAI-1)水平并与25例正常体检者进行对比分析。结果CHF患者血浆VWF、P-选择素、PAI-1水平较正常对照组明显升高,且三者水平与心功能状态有关。P-选择素与VWF呈正相关关系。结论CHF患者存在内皮损伤、血小板激活以及纤溶活性降低,提示CHF患者有高凝倾向,易血栓形成。

作者卢薇梁英梅邹平

机构地区贵州省贵阳市第二人民医院

出处《海南医学》 CAS 2009年第3期44-45,共2页 Hainan Medical Journal

关键词心力衰竭血管性血友病因子 P-选择素纤溶酶原激活物抑制因子

分类号 R541.6 [医药卫生—心血管疾病]

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