甲状腺恶性肿瘤的彩色多普勒超声血流参数及TGF-β1与颈部淋巴结转移的关系

Relationship between intratumoral blood flow parameter assessed by color Doppler,TGF-β1 and cervical lymph node metastasis in malignant thyroid masses

目的：探讨彩色多普勒血流显像（CDFI）检测甲状腺恶性肿块的血流、肿瘤组织的转化生长因子-β1（TGF—β1）与颈部淋巴结转移的关系。方法：运用CDFI检测26个甲状腺恶性肿块（经手术病理证实）的血流并进行血流参数测定，同时术后采用免疫组织化学技术对肿瘤内TGF—β1进行计数，分析血流参数与TGF—β1间是否存在相关性。结果：甲状腺恶性肿瘤伴淋巴结转移组的收缩期峰值流速（SPV）、血流阻力指数（RI）值及TGF-β1计数均高于无淋巴结转移组，且TGF—β1与SPV、TGF—β1与RI存在明显正相关。结论：彩色多普勒血流参数测定对甲状腺恶性肿瘤是否伴颈部淋巴结转移有重要参考价值。

Objective：To explore the relationship between intratumoral blood flow assessed by color Doppler, transforming growth faetor-β1 （TGF-β1） and cervical lymph node metastasis in malignant thyroid masses. Methods： Detect 26 malignant thyroid masses （confirmed by pathology） by CDFI and observe blood parameters ,also TGF-β1 was derived from immunohist-chemisty technique,last the correlations among SPV, RI and TGF-β1 were analyzed. Results ：The intratumoral TGF-β1 incidence ,SPV and RI of malignant thyroid masses accompanyed with cervical lymph node metastasis was significantly higher than that of not with cervical lymph node metastasis. SPV and RI detected by color Doppler ultrasound are positively correlated with TGF-β1. Conclusion：The color Doppler blood parameters are very useful in differentiating wheher malignant thyroid masses accompanyed with cervical lymph node metastasis or not.