119例恶性血液病患者医院感染分析

Analysis of nosocomial infection in 119 patients with hematological malignant disease

目的：探讨恶性血液病医院感染的危险因素、病原体种类、感染部位等。方法：对119例恶性血液病患者医院感染进行回顾性调查分析。结果：119例恶性血液病患者化疗发生医院感染62例，占52．1％，以呼吸道感染最常见（46．0％），病原学以革兰阴性杆菌最多（55．1％），其次是真菌（23．0％）。粒细胞缺乏组感染率82．8％，非粒细胞缺乏组感染率42．2％。结论：化疗、粒细胞缺乏、大量使用抗生素是医院感染、真菌感染常见的危险因素。

Objective：To study the risk factors, pathogen classes and the infection locations in patients with hematological malignant diseases. Methods：Nosocomial infections in 119 patients with hematological malignant diseases were analyzed retrospectively. Results：Sity-two cases developed nosocomial infection after doing chemotherapy,and the proportion was 52.1% ,Respiratory infection was the most common infection location,and the ratio was 46.0%. The infection rate of the gram-negative bacilli was 55.1% ,the fungus was 23.0%. The infection rate of patients with agranulocytosis was 82.8 %,while the non-agranulocytosis group had the rotio of 42.2 %. Conclusion zChemotherapy, agranulocytosis and over applying the antibiotics were the main factors of nosocomial infection.