MTBE合成2,5-二叔丁基对苯二酚的研究

Synthesis of 2,5-Di-(tert- butyl)Hydroquinone by Methyl Tert-Butyl Ether

以甲基叔丁基醚(MTBE)和对苯二酚为原料、硫酸为催化剂,合成2,5-二叔丁基对苯二酚(DBHQ)。用正交实验分别考察了酚醚摩尔比、催化剂用量及反应时间3个因素对DBHQ收率的影响并进一步探讨了对粗产品的精制方法。实验结果表明,合成DBHQ的适宜工艺条件为:酚醚摩尔比为2.1∶1,酚酸摩尔比为1∶0.1,反应时间为1.5h,反应温度为90℃,分离所用乙醇与水的体积比为1∶2。在此条件下,2,5-二叔丁基对苯二酚的质量分数为99%以上,平均收率为60%。

Synthesis of 2,5-di-（tert-butyl）hydroquinone（DBHQ） by alkylation of hydroquinone with methyl tert-butyl ether （MTBE） was studied. The optimum was discussed with the method of orthogonal design. The effects of reaction time, molar ratio of hydroquinone and MTBE and solvent dosage on the yield of DBHQ were also investigated. The optimum conditions for synthesizing DBHQ are as follows： n（hydroquinone）/n（MTBE）） is 2.1 = 1,n（hydroquinone）/n（catalyst） is 1 ： 0.1,the reaction temperature is about 90 ℃, the reaction time is 1.5 h,volume ratio of alcohol and water is 1 ： 2. Under the optimum conditions, the content of DBHQ in the product is above 99%, the average yield of DBHQ is 60%.