丹红注射液、复方丹参注射液治疗老年非ST段抬高急性冠脉综合征的疗效对比

Comparision of the curative effects of danhong injection vs compound danshen injection in the treatment for the elderly patients with non-ST-elevation acute coronary syndrome

目的比较丹红注射液、复方丹参注射液治疗老年非ST段抬高急性冠脉综合征(NSTE-ACS)的疗效及安全性。方法将79例患者随机单盲分为丹红组(A组)39例和丹参组(B组)40例。A组给予丹红注射液20ml,1次/d;B组给予复方丹参注射液20ml静滴,1次/d。两组均连续30d,观察临床症状、心电图变化、测定C-反应蛋白(CRP)、纤维蛋白原(Fg)等,观察心脏事件发生率。结果A组与B组症状疗效总有效率分别为94.9%和82.5%,差异有统计学意义(P<0.05);两组心电图有效率分别为87.2%和65%,差异有统计学意义(P<0.05);两组CRP、Fg均较治疗前明显降低(P<0.01),A组与B组相比有统计学意义(P<0.01);A组心脏事件发生率有降低趋势。结论丹红注射液治疗老年NSTE-ACS疗效优于复方丹参注射液,安全性高,依从性好。

Objective To compare the curative effects and safety of danhong injection and compound danshen injection in the treatment for the elderly patients with non - ST - elevation acute coronary syndrome （ NSTE - ACS） o Methods 79 elderly patients were randomly divided into two groups treatment group （ group A, n = 39） and control group （group B,n =40） ,Patiens in group A were given danhong injection 20 ml iv drip qd, in group B were given compound danshen injection 20ml iv drip qd. Before and 30 days after the treament, test the C - reactive protein （ CRP）, fibrinogen （Fg） ,the change in clinical symptoms ,electrocardiology and hem orrheology , the incidence rate of cardiovascular event were observed. Results The total effective rate for the two groups were 94.9% and 82.5%, Total effective rate of electrocar diology for the two groups were 87.2% and 65%, significant differences was found between the treament group and control group （ P 〈 0.05 ）. The CRP, Fg were lower than that before treatment in the two groups （ P 〈 0.01 ）, and it was significantly lower comparing to B group（P 〈0.01 ）. the incidence rate of the cardiovascular event has a tendency to become lower in A group than that in B group. Conclusion Danhong injection is better than compound injection of danshen and has higher safety and better compliance in the treatment of elderly patients with NSTE - ACS.