老年男性骨质疏松与动脉粥样硬化相关性的研究

Relationship between osteoporosis and atherosclerosis in elderly male people

目的探讨老年男性人群中骨质疏松与动脉粥样硬化之间的相关性。方法以93例老年医学科住院男性患者为研究对象,采用双能X线吸收法(dual-energy X-ray absorptiometry,DXA)测定腰椎骨和股骨区的骨密度(BMD);同时采用超声探查颈动脉内中膜厚度(intima-media thickness,IMT)及粥样斑块的情况。结果在骨质疏松组(46例)中,存在内膜增厚者38例(82.61%),粥样斑块34例(73.91%),与非骨质疏松组比较,骨质疏松组在动脉内中膜增厚(IMT≥0.9mm)及粥样斑块的发生率上均明显升高(P<0.05);而内中膜增厚组(67例)及斑块组(57例)的BMD分别较其对照组低,并在NECK、WARDs三角、TORCH等部位具有统计学差异(P<0.05)。结论老年男性骨质疏松人群较非骨质疏松人群更易发生动脉粥样硬化病变,同时存在动脉粥样硬化病变的人群也易致骨量的丢失。提示骨质疏松与动脉粥样硬化之间可能存在着共同危险因素。

Objective To observe the relationship between osteoporosis and atherosclerosis in elderly male people. Methods Ninetythree elderly male inhospital patients were enrolled.All patients underwent ultrasonography of the both sides＇ carotid arteries.Intimamedia thickness（IMT）,atherosclerotic plaques were measured.They also underwent DXA examination to determine the bone mineral density （BMD）of the vertebra and the femoral head. Results In osteoporosis group（46 cases）,there were 38 cases（82.61%）with IMT≥0.9 mm,and 34 cases（73.91%）had atherosclerotic plaques.Compared with the nonosteoporosis group, the osteoporosis group had a higher prevalence of increased IMT and atherosclerosis plagues.BMD was lower in IMT≥0.9 mm group（67 cases）and atherosclerosis plagues group（57 cases）,and was significantly different（P〈0.05） in NECK,WARDs and TORCH. Conclusions Elderly male people with osteoporosis may have increased prevalence of atherosclerosis diseases;Meanwile people with atherosclerosis tend to have lower BMD.There may be some common risk factors between osteoporosis and atherosclerosis in elderly male people.