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Notch/Jagged1信号通路与内皮祖细胞的增殖分化 被引量：1

Notch/Jagged1 Signal Pathway and Endothelial Progenitor Cells’Proliferation or Differentiation
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摘要 目前对Notch配体和受体之间的信号转导已有大量的研究。它分布广泛，在无脊椎动物和脊椎动物中起重要作用。近年来，在对血管增殖分化的研究中，Notch／Jagged1的研究颇为热门，它对血管增殖分化的双重调节作用对临床治疗心脏和血管疾病是一大进展。 Currently,there are many research about Notch ligand and receptor. They are widely distributed and play a critical role on invertebrate and vertebrate. In recent years,in the research of vascular proliferation or differentiation,the research of Notch/Jaggedl become hot The double regulation of vascular proliferation or differentiation has a big advancement to treat heart and vascular disease in clinic.
作者 李小林 范忠才
机构地区 泸州医学院附属医院心内科
出处 《医学综述》 2009年第5期653-655,共3页 Medical Recapitulate
关键词 Notch/Jagged1信号通路 内皮祖细胞 增殖 分化 Notch/Jagged1 signaling pathway Endothelial progenitor cells Proliferation Dif- ferentiation
分类号 R54 [医药卫生—心血管疾病]
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参考文献30

  • 1Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development [ J ]. Science, 1999,284 (5414) :770-776.
  • 2Milner LA,Bigas A. Notch as a mediator cel fate determination in hematopoiesis : evidence and speculation [J]. Blood, 1999,93 (8) : 2431-2448.
  • 3骆志清,王毅,罗志刚.Notch信号通路在诱导免疫耐受作用中的研究进展[J].临床和实验医学杂志,2008,7(1):139-141. 被引量：7
  • 4de La Coste A, Freitas AA. Freitas Notch signaling:distinct ligands induce specific signals during lymphocyte development and maturation [ J ]. hnmumol Lett,2006,102 ( 1 ) :1-9.
  • 5Hrabe de Angehs M, McIntyre J 2nd, Gossler A. Maintenance of somite borders in mice requires the Delta homologue DI[J]. Nature, 1997,386( 15 ) :717-721.
  • 6Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling[J]. Genes Dev ,2007,21 (20) :2511-2524.
  • 7Holland LZ, Rached LA,Tamme R, et al. Characterization and develop-mental expression of the amphioxus homolog of Notch ( Amphi Notch) : evolutionary conservation of multiple expression domains in am phioxus and vertebrates [J]. Dev Biol, 2001,232 ( 2 ) : 493-507.
  • 8Kojika S, Grifin JD. Notch receptors and hematopoiesis [ J ]. Exp Hematol,2001,29 ( 9 ) : 1041-1052.
  • 9Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple efectors of the Notch signaling pathway [ J ]. J Ceil Physiol, 2003, 194 ( 3 ) : 237 -255.
  • 10Katoh M. Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES ceils, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer [J]. Int J Oncol, 2007,31 ( 2 ) :461-466.

二级参考文献10

  • 1Artavanis-Tsakonas S,,Rand MD,Lake RJ.Notch signaling:cell fate control and signal integration in development[].Science.1999
  • 2Milner LA,Bigas A.Notch as a mediator cell fate determination in hem-atopoiesis:evidence and speculation[].Blood.1999
  • 3Iso T,Kedes L,Hamamori Y.HES and HERP families:multiple effectors of the Notch signaling pathway[].Journal of Cellular Physiology.2003
  • 4Holland LZ,Rached LA,Tamme R,et al.Characterization and develop-mental expression of the amphioxus homolog of Notch(AmphiNotch):evolutionary conservation of multiple expression domains in amphioxus and vertebrates[].Developmental Biology.2001
  • 5Wilson A,MacDonald HR,Radtke F.Notch1-deficient common lymphoid precursors adopt a B cell fate in the thymus[].The Journal of Experimental Medicine.2001
  • 6Radtke F,Ferrero I,Wilson A,et al.Notch l deficiency dissociates the intrathymic development of dendritic cells and Tcells[].The Journal of Experimental Medicine.2000
  • 7Cheng P,Zlobin A,Volgina V,et al.N Notch-1regulates NF-kappaB activity in hemopoietic progenitor cells[].J Immunol.2001
  • 8Ohishi K,Varnum-Finney B,Serda RE,et al.The Notch ligand,Delta-1,inhibits the differentiation of monocytes into macrophages but per-mits their differentiation into dendritic cells[].Blood.2001
  • 9Freddy Radtke Anne Wilson and H Robson MacDonald.Notch signaling in T- and B-cell development[].Current Opinion.2004
  • 10Anderson AC,Robey EA,Huang YH.Notch signaling in lymphocyte development[].Curr Opin Genet Dev.2001

共引文献6

同被引文献15

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二级引证文献6

医学综述
2009年 第5期

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