肝星形细胞、肌纤维母细胞和原发性肝癌的关系

Relationship between Hepatic Stellate Cell,Myofibroblast and Primary Hepatic Carcinoma

原发性肝癌是常见的恶性肿瘤之一，它严重地威胁着人类的健康。原发性肝癌的发生是一个多因素、多步骤的复杂过程。在我国，原发性肝癌多发生在多年的肝硬化基础之上。近年来，越来越多的研究发现，肝纤维化、肝硬化是各种慢性肝病的最终结局。原发性肝癌与肝硬化存在密切联系；肝纤维化、肝硬化、肝癌都是肝实质细胞与肝间质细胞共同作用的结果。本文就肝肌纤维母细胞与原发性肝癌发生的关系研究现状予以综述。

Primary hepatic carcinoma（PHC） is a common malignant tumour and threaten human health severely. The occurrence of PHC is multiplicity of multiple factor and procedure. In our country, PHC happen on the foundation of liver cirrhosis with many years. In recent years, more and more research find that hepatic fibrosis and liver cirrhosis are the final result of chronic liver disease. PHC has a intimate relation to liver cirrhosis;. Liver fibroblast, cirrhosis and hepatocellular carcinoma are all the results of parenchymal liver ceils and mesenchymal ceils. The article reviews the recent studies of relationship between myofibroblast and PHC.