营养元素调控热休克蛋白研究进展

A Review on the Effelts of Nutritive Elements on the Expression of Heat Shock Protein

热休克蛋白(Heat Shock Protein,HSP)是生物体在受热或其他不利环境因素刺激下应激合成的一组特殊蛋白质.HSP的生物学功能广泛,不仅表现在热应激条件下参与细胞的抗损伤、修复和热耐受过程,保护细胞生命活动,而且在蛋白质折叠、跨膜运输、细胞骨架及核骨架稳定等方面发挥重要作用.由于机体的营养状况与应激能力密切相关,本文主要综述了营养元素对HSP合成的调控作用.

The heat shock protein （HSP） is produced by stress factors, and it can produce a series of corresponding physiological reactions to slow down the cell damage. As the molecular companion, the heat shock response assists the protein in transporting among the cell organs, and it assists the newborn peptide chain to fold and prevent it from making any mistakes when folding. In addition, HSP plays an important role in stabilization of karyon cytoskeletonic system and modulates the process of fetation. Since nutrition state stress correlates with anti-stress ability, nutritional supplements can increase anti-stress ability. In this paper, the effects of nutritive elements on the expression of HSP are reviewed.