阿司匹林在颅内动脉瘤支架辅助栓塞术后的应用

Application of aspirin following stent-aiding embolism operation for cerebral aneurysm

目的探讨阿司匹林在颅内动脉瘤支架辅助栓塞术后应用的时间和疗效。方法选择2005年1月-2008年6月我院48例颅内动脉瘤支架辅助栓塞术后患者,随机分为阿司匹林组和对照组,阿司匹林组给予阿司匹林(100mg,1次/d)口服,3个月、6个月后各行1次血常规及凝血检查;3个月后行DSA检查,评价动脉瘤形状及患者神经功能情况。结果3个月内,口服阿司匹林较未口服阿司匹林患者发生神经功能缺失明显减少,P<0.05;口服阿司匹林6个月的患者发生神经功能缺失情况与口服3个月组比较,P>0.05。口服阿司匹林患者血常规及凝血、动脉瘤形状无明显变化。结论颅内动脉瘤支架辅助栓塞术后口服阿司匹林3个月可达到防治患者神经功能缺失作用,不增加术后动脉瘤复发的发生危险或引起动脉瘤破裂。

Objective To investigate the application of aspirin being given after stent-alding embolism operation for cerebral aneurysm. Methods 48 patients with cerebral aneurysm after stent-aiding embolism operation were randomly divided into 2 groups. Treatment group was treated with aspirin （100 mg, once per day） , and the control group was given placebo. In the treatment group, the blood routine and blood clotting was examined after 3 months and 6 months respectively, DSA was examined after 3 months. Results Loss of neuro-function in patients of treatment group was lower than that of control group,P 〈0.05. In treatment group,there was no significant difference in variation of neuro-function between the patients treated for 3 months and 6 months, P 〉 0.05. Blood routine, blood clotting and the shape of aneurysm of treatment group bad no obvious change. Conclusion Aspirin has control effect on loss of neuro-function when used for 3 months after stent-aiding embolism operation for cerebral aneurysm, and it did not raise the recrudescence of aneurysm or disruption of aneurysm after operation.