PTEN在膀胱移行细胞癌中的表达缺失和意义

Loss expression and its clinical significance of PTEN gene in bladder transitional cell carcinoma

目的探讨PTEN基因在膀胱移行细胞癌中的表达缺失及其临床意义。方法用免疫组织化学SP法检测62例膀胱移行细胞癌和10例正常膀胱组织中PTEN蛋白的表达。结果PTEN蛋白在正常膀胱组织均为阳性,在膀胱移行细胞癌中阳性表达率为46.77%(29/62)。随肿瘤恶性程度的增高,PTEN蛋白表达减少,Ⅰ级与Ⅲ级比较,差异有统计学意义(P<0.01);随临床分期的增高,PTEN蛋白表达减少,但差异无统计学意义(P>0.05)。结论PTEN基因与膀胱移行细胞癌病理分级、临床分期密切相关,PTEN蛋白异常表达可作为膀胱移行细胞癌肿瘤标志物。

Objective To investigate the loss expression and its clinical significance of PTEN gene in bladder transitional cell carcinoma. Methods The expression of PTEN gene was studied by SP immunohistochemisty in 10 cases of the normal bladder tissues and 62 cases of the bladder transitional cell carcinoma. Results All the normal bladder tissues showed positive staining pattern of PTEN protein, positive rate of PTEN protein in 62 cases of the bladder transitional cell carcinoma was 46.77 % （29/62） , the difference was significant（P 〈0.01 ）. The difference of positive rate between Grade I and Grade m cases was significant （P 〈0.05）. The higher the clinical stage,the lower the PTEN protein positive rate,but the difference wasn＇t significant （ P 〉 0.05 ）. Conclusion The abnormal expression of PTEN protein have correlation with grade and stage. It can be regarded as a new useful diagnostic marker in the bladder transitional cell carcinoma.