期刊文献+

血清/尿PSA比值对血清PSA处于“灰区”中前列腺癌的诊断价值 被引量:2

The role of the ratio of serum PSA and urine PSA in diagnosing prostate carcinoma within the serum PSA "gray" zone
原文传递
导出
摘要 目的探讨血清前列腺特异性抗原(sPSA)与尿前列腺特异性抗原(uPSA)比值(s/uPSA)对血清PSA处于诊断"灰区"——sPSA于4.0~10.0ng/ml(放射免疫法范围)前列腺癌的诊断价值。方法选择血清PSA(sPSA)于诊断"灰区"的共191例前列腺疾病患者,采用放射免疫方法检测其尿PSA(uPSA)水平,根据前列腺活检结果分为前列腺癌组(PCa组,n=76)和良性前列腺增生症组(BPH组,n=115),比较两组s/uPSA比值以及两组间sPSA和s/uPSA比值的受试者运算特性曲线(ROC)面积。结果BPH组与PCa组的sPSA分别为(5.20±1.09)ng/ml和(6.41±2.12)ng/ml,uPSA分别(3.57±0.97)ng/ml和(2.17±0.61)ng/ml,sPSA和uPSA在BPH组与PCa组两者间差别均无统计学意义(t=0.91,t=1.24,P>0.05);BPH组与PCa组的s/uPSA分别为(2.32±0.61)和(4.13±1.09),PCa组s/uPSA比值明显高于BPH组,差别具有统计学意义(t=4.17,P<0.01)。s/uPSA比值和sPSA的ROC曲线下面积分别为0.836和0.703。在保持95%敏感性时,s/uPSA比值和sPSA的特异性分别为77.1%和39.6%。结论在血清PSA值4.0~10.0ng/ml范围内,s/uPSA比值较sPSA更好地检出前列腺癌;在保持同一敏感性时,s/uPSA较sPSA具有更高的特异性。 Objective To evaluate the value of serum and urine prostate specific antigen ratio (s/u PSA)in diagnosing patients with prostate carcinoma (PCa) whose serum PSA (sPSA) concentration is between 4.0 ng/ml and 10.0ng/ml. Methods A total of 191 consecutive patients with prostate diseases whose sPSA concentration ranged from 4.0 ng/ml to 10.0ng/ml were accessed. The sPSA and uPSA concentration of all patients was analyzed by radioimmunologic assay and the s/u PSA ratios were calculated. According to the results of prostate biopsy, the patients were divided into two groups: PCa group (n=76) and benign prostate hyperplasia (BPH) group (n=115). The receiver operating characteristic (ROC) curves were generated by plotting the sensitivity versus specificity. Area under the cures was calculated for each assay. Results There was no statistically significant difference in both sPSA and uPSA levels between BPH group and PCa group (5.20±1.09ng/ml vs 6.41±2.12ng/ml; 3.57±0.97 ng/ml vs 2.17±0.61 ng/ml respectively )(t=0.91, t= 1.24, P〉0.05, respectively). However, the s/u PSA ratios in PCa group were higher than those in BPH group (4.13±1.09 vs 2.32±0.61, t=4.17, P〈0.01). Area under the ROC curves of s/u PSA ratio and sPSA were 0.836 and 0.703 respectively. The specificity of s/u PSA ratio and sPSA were 77.1% and 39.6% respectively at cutoffs yielding 95% sensitivity. Conclusions The s/u PSA ratio can provide better differential effect of PCa and BPH than traditional sPSA when sPSA concentration ranges from 4.0 ng/ml to 10.0ng/ ml. At the same sensitivity, s/u PSA has a higher specificity than sPSA.
出处 《中华腔镜泌尿外科杂志(电子版)》 2008年第3期52-55,共4页 Chinese Journal of Endourology(Electronic Edition)
关键词 前列腺特异性抗原 前列腺肿瘤 Prostate specific antigen Prostatic neoplasms Carcinoma
  • 相关文献

参考文献11

  • 1Shingo Yamamoto,Takuo Maruyama,Nobuyuki Kondoh,Michio Nojima,Hidekazu Takiuchi,Seiichi Hirota,Hiroki Shima.Diagnostic efficacy of free to total ratio of prostate-specific antigen and prostate-specific antigen velocity, singly and in combination, in detecting prostate cancer in patients with total serum prostate-specific antigen between 4 and 10?ng/ml[J].International Urology and Nephrology.2008(1)
  • 2Yamamoto S,Maruyama T,Kondoh N,et al.Diagnostic efficacy of free to total ratio of prostate-specific antigen and prostate-specific antigen velocity,singly and in combination,in detecting prostate cancer in patients with total serum prostate-specific antigen between4and10ng/ml[].International Urology and Nephrology.2008
  • 3Lilja H,Christensson A,Dahlen U,et al.Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin[].Clinical Chemistry.1991
  • 4Jung K,Elgeti U,Lein M,et al.Ratio of free or complexed prostate-specific antigen(PSA) to total PSA: which ratio improves differentiation between benign prostatic hyperplasia and prostate cancer[].Clinical Chemistry.2000
  • 5Richard Lee A. Russell Localio Katrina Armstrong f S. Bruce Malkowicz a hre.A meta-analysis of the performance characteristics of the free prostate-specific antigen test[].Urology.2006
  • 6Ferdimand M,Leone C,Antonella C,et al.High concentrations of prostate-specific antigen urine of women oral contraceptive[].Clinical Chemistry.1998
  • 7Graves HC,Wehner N,Stamey TA.Ultrasensitive radioimmunoassay of prostate specific antigen[].Clinical Chemistry.1992
  • 8Ornstein,DK,Rayford,W,Fusaro,VA.Serum proteomic profiling can discriminate prostate cancer from benign prostates in men with total prostate-specific antigen levels between 2.5 and 15.0 ng/ml[].Journal d Urologie.2004
  • 9Karazanashvili G,Abrahamsson PA.Prostate specific antigen and human glandular kallikrein 2 in early detection of prostate cancer[].Urology.2003
  • 10Kuriyama M,Abrahamsson PA,Imai K, et al.Determination of serum prostate-specific antigen-alpha1-antichymotrypsin complex for diagnosis of prostate cancer in Japanese cases[].Scandinavian Journal of Urology and Nephrology.2001

同被引文献17

  • 1肖志刚,夏向南.安多霖联合氟他胺治疗前列腺癌13例近期疗效分析[J].中国误诊学杂志,2009,9(6):1472-1473. 被引量:2
  • 2朱生才,刘明,王建业.血清前列腺特异抗原4~10μg/L的前列腺癌“灰区”的诊断和治疗[J].中华老年医学杂志,2006,25(4):269-271. 被引量:10
  • 3廖辉,刘锦华,钱辉军,吕胜启.间歇性内分泌治疗与放射性粒子^(125)Ⅰ植入联合应用治疗晚期前列腺癌[J].中国男科学杂志,2007,21(3):34-36. 被引量:5
  • 4ORNSTEIN D K,RAYFORD W,FUSARO V A,et al.Serum proteomic profiling can discriminate prostate cancer from benign prostates in men with total prostate specific antigen levels between 2.5 and 15.0 ng/ml[J].J Urol,2004,172(4 Pt 1):1302-1305.
  • 5SHEIKH M,AL-SAEED O,KEHINDE E O,et al.Utility of volume adjusted prostate specific antigen density in the diagnosis of prostate cancer in Arab men[J].Int Urol Nephrol,2005,37(4):721-726.
  • 6OESTERLING J E,TEKCHANDANI A H,MARTIN S K,et al.The periurethral glands do not significantly influence the serum prostate specific antigen concentration[J].J Urol,1996,155(5):1658-1660.
  • 7IRANI J,SALOMON L,SOULI(E) M,et al.Urinary/serum prostate-specific antigen ratio:comparison with free/total serum prostate-specific antigen ratio in improving prostate cancer detection[J].Urology,2005,65(3):533-537.
  • 8CATALONA W J,SOUTHWICK P C,SLAWIN K M,et al.Comparison of percent free PSA,PSA density,and age-specific PSA cutoffs for prostate cancer detection and staging[J].Urology,2000,56(2):255-260.
  • 9ASLAN G,IRER B,KEFI A,et al.The value of PSA,free-to-total PSA ratio and PSA density in the prediction of pathologic stage for clinically localized prostate cancer[J].Int Urol Nephrol,2005,37(3):511-514.
  • 10齐隽,康健,陈方,陈建华,张良,孔良,王伟明,白强.前列腺特异性抗原灰区的前列腺癌临床资料分析[J].中国男科学杂志,2007,21(11):33-35. 被引量:9

引证文献2

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部