肺癌MMP-9和VEGF的表达及意义

Expression of MMP-9 and VEGF in lung carcinoma and their significances

目的探讨肺癌组织中基质金属蛋白酶-9(MMP-9)和血管内皮生长因子(VEGF)的表达及其意义。方法采用免疫组化S-P法检测20例癌旁正常肺组织、84例肺癌组织中MMP-9和VEGF的表达。结果肺癌组织MMP-9和VEGF表达显著高于癌旁正常肺组织(P<0.01)。小细胞肺癌和腺癌MMP-9表达高于鳞癌(P<0.01)。肺癌MMP-9表达有淋巴结转移者高于无淋巴结转移者(P<0.01),Ⅲ期和Ⅳ期高于Ⅰ期和Ⅱ期(P<0.05)。肺癌VEGF表达有淋巴结转移者高于无淋巴结转移者(P<0.05),Ⅲ期和Ⅳ期高于Ⅰ期和Ⅱ期(P<0.05)。肺癌MMP-9和VEGF的表达呈正相关(P<0.05)。结论MMP-9和VEGF表达与肺癌侵袭转移密切相关。

Objective To investigate the expression of MMP-9 and VEGF in lung carcinoma tissue and their significances. Methods The expression of MMP-9 and VEGF was detected in 84 lung carcinoma tissues and 20 para-cancerous nor- real lung tissues by immunohistochemieal method. Results The expression of MMP-9 and VEGF in lung carcinoma tissues was significantly higher than that in para-cancerous normal lung tissues （P〈0.O1）. Small cell lung cancer and adenocarcinoma had higher MMP-9 expression than squamous cell carcinoma （P〈0.01）. The expression of MMP-9 was significantly higher in lung carcinomas with lymph node metastasis than in lung carcinomas without lymph node metastasis（P〈0.01）, was significantly higher in stage-Ⅲ and stage-Ⅳ tumours than in stage- Ⅰ and stage-Ⅱ turnouts （P〈0.05）. The expression of VEGF was significantly higher in lung carcinomas with lymph node metastasis than in lung carcinomas without lymph node metastasis（P〈0.05）, was sig- nificantly higher in stage-Ⅲ and stage-Ⅳ tumours than in stage- Ⅰ and stage-Ⅱ tumours （P〈0.05）. The expression of MMP-9 correlated positively with that of VEGF in lung carcinomas （P〈0.05）. Conclusion The expression of MMP-9 and VEGF is closely correlated with invasion and metastasis of lung carcinoma.