15% polyphenon E乳膏治疗尖锐湿疣有效性与安全性的Meta分析

Efficacy and safety of 15% polyphenon E cream in the treatment of condyloma acuminatum:a Meta analysis

目的评价15% polyphenon E乳膏治疗尖锐湿疣的有效性和安全性。方法应用国际Cochrnae协作网系统评价方法,计算机检索Cochrane图书馆、MEDLINE、EMBASE、CBM,手工检索中华皮肤科杂志、中国皮肤性病学杂志、临床皮肤科杂志、国外医学(皮肤病与性病分册)杂志和参考文献,纳入15% polyphenon E乳膏治疗尖锐湿疣的随机对照试验,由两名研究者独立提取资料并进行方法学质量评估,对符合纳入标准的研究采用RevMan4.3软件进行Meta分析。结果共纳入3个随机对照试验(RCT),包括1247例尖锐湿疣患者。Meta分析结果显示15%polyphenon E乳膏疣体完全清除率优于安慰剂,差异有统计学意义;15% polyphenon E乳膏与10% polyphenon E乳膏疣体完全清除率相当。不良反应主要为局部炎症反应,包括红斑、烧灼、瘙痒、水肿等,多为轻中度。结论15%polyphenon E乳膏治疗尖锐湿疣是安全有效的。

Objective To assess the efficacy and safety of 15% polyphenon E cream in the treatment of condyloma acuminatum. Methods According to international Cochrane Collaboration, the electronic databases were searched from the Cochrane library, MEDLINE, EMBASE and CBM. Chinese Jounal of Dermatology, Chinese Journal Of Dermatovenerology, Journal of Clinical Dermatology and Foreign Medical Sciences（ Section of Dermatology and Venereology）and references of above searched articles were searched manually. The randomized controlled trials（RCTs） about 15% polyphenon E cream in the treatment of condyloma acuminatum were included. Two authors independently reviewed the data and assessed the quality. The data were input and analyzed by RevMan 4.3 software. Results Three randomized controlled trials（RCT） involving 1 247 patients met the inclusion criteria. Meta analysis showed the clinical effective rate of 15% pelyphenon E cream was significantly higher than that of placebo, but not higher than that of 10% pelyphenon E cream. Commonly reported adverse events were focused on erythema, burning, itching and oedema, and most of them were mild or moderate. Conclusion Topical 15% polyphenon E cream is an effective and safe regimen for treating condyloma acuminatum.