急性脑梗死患者治疗前后血浆Hcy和血清脂联素检测的临床意义

Clinical Significant of Measurement of Plasma Hcy and Serum Adiponectin Levels After Treatment in Patients with Acute Cerebral Infarction

目的:探讨急性脑梗死患者治疗前后血浆Hcy和血清脂联素水平的变化及临床意义。方法:应用放射免疫分析和ELISA对36例急性脑梗死患者进行了血浆Hcy和血清脂联素的测定,并与35名正常健康人作比较。结果:在治疗前血浆Hcy水平非常显著高于正常人组(P<0.01),而血清脂联素水平则非常显著低于正常人组(P<0.01),经3个月治疗后,血浆Hcy水平和血清脂联素水平与正常人比较仍有显著差异(P<0.05),血浆Hcy水平与血清脂联素水平呈明显的负相关(r=-0.4021,P<0.05)。结论:检测急性脑梗死患者血浆Hcy和血清脂联素水平的变化对了解病情、观察预后均有重要的临床价值。

Objective To explore the clinical significance of changes of plasma Hcy and serum adipondctin levels after treatment in patients with acute cerebral infarction. Methods Plasma Hcy （with RIA） and serum adiponectin （with ELISA） levels were determined in 36 patients with acute cerebral infarction both before and after treatment as well as in 35 controls. Results Before treatment, the plasma Hcy levels were significantly higher than those in controls （P 〈 0.01 ）, while serum adiponectin levels were significantly lower than those in controls （P 〈0.01）, After treatment for three months, the levels, though corrected markedly, remained significantly different from those in controls （ P 〈 0.05）. Plasma Hcy levels were negatively correlated with sercam adipornection levels （r = - 0. 4021, P 〈 0.05）. Conclusion Plasma Hcy and serum adiponectin levels were closely related to the diseases process of acute cerebral infarction and determination of which were of great Clinical importance.