PAI-1基因4G/5G多态性与内蒙地区IgA肾病的相关性研究

Study on the Relation Ship Between Plasminogen Activator Inhibitor-1(PAI-1) Gene 4G/5G Polymorphism and IgA Nephropathy in Inner Mongolia Resion

目的:探讨纤溶酶原活化物抑制剂-1(plasminogen activator inhibitor-1,PAI-1)基因启动子区4G/5G多态性与内蒙地区IgA肾病的相关性。方法:随机收集包头医学院第一附属医院肾内科IgA肾病患者100例,另设100名健康体检者为对照组。采用等位基因特异聚合酶链反应(ASPCR)法进行PAI-14G/5G基因型分析。结果:IgA肾病组的4G/4G基因型发生频率(41%)显著高于对照组(23%,P值<0.01)。4G、5G等位基因频率比较无统计学差异(χ2=1.818,P>0.05)。结论:PAI-14G/4G基因型是内蒙地区IgA肾病发病的易感基因型,但PAI-14G等位基因不是内蒙地区IgA肾病的易感基因。

Objective To investigate whether the PAI- 1 gene polymorphism played a role in IgA nephropathy in Inner Mongolia Region. Methods The genotypes of the 4G/5G allelie polymorphism in the PAI- 1 gene promoter region were examined with allele specific polymerase chain reaction （ASPCR） from the peripheral blood leukocytes in one hundred patients with IgA nephropathy and one hundred controls. Results Genotype frequencies of PAI - 1 4G/4G （41%） in patients with IgAN were higher than that in controis （23%） （ P 〈 0.05 ）. Conclusion PAI- 1 4G allele homozygous genotype might be a major risk factors of IgA nephropathy in Inner Mongolia Region.