血脂异常与2型糖尿病和性别的相关研究 社区人群心脑血管事件前瞻性研究系列之六

The relationship of blood-lipid disorder with the prevalence of type 2 diabetes mellitus and sex in the people of Nanning city,Guangxi province

目的研究血脂异常与2型糖尿病和性别的关系。方法将广西南宁市年龄36～78岁,平均年龄(54.23±9.87)岁的1072人分为2型糖尿病组与正常组,测定甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及腰围(Waist)、体重指数(BMI)等相关指标,探索血脂异常与2型糖尿病和性别关系。结果①与正常组相比,2型糖尿病组总胆固醇(TC),甘油三酯(TG),高密度脂蛋白(HDL)含量有显著性差异(P分别为0.0081、0.0015、<0.0001)。②甘油三酯和胆固醇异常为糖尿病的风险因素,男性高胆固醇(TC)与糖尿病的关联比女性大(OR1.93:1.49),女性高甘油三酯(TG)与糖尿病的关联比男性大(OR2.49:1.46)。结论2型糖尿病患者血脂比健康人群高,应预防高血脂,降低疾病风险。血脂含量异常与糖尿病、性别具有相关关系。

Objective To investigate the relationship of blood-lipid disorder with the prevalence of type 2 diabetes mellitus （T2DM） and sex in the people of Nanning city,Guangxi province. Methods The 1072 people were divided into T2DM group and control group. Total cholesterol（TC）,Triglyceride （TG）,high density lipoprotein-cholesterol（HDL-C）,low density lipoprotein-cholesterol（LDL-C） and some other related indexes were measured in the patients group（n=411） and the control group（n=661）.The result between the two groups were compared. Results ①In comparison with control group,TC,TG and HDL-C of patients with T2DM were significantly higher（P=0.0081,0.0015,〈0.0001 respectively）. ②TG and TC were risk factors of T2DM for both male and female,high TC was more related to the male in prevalence of T2DM than female （OR 1.93：1.49）and high TG was more related to female（OR 2.49：1.46）. Conclusions Lipids disorders is commonly existed in diabetic patients,and related to sex.