摘要
目的研究治疗性生活方式改变加药物对社区人群糖代谢的干预效果。方法采用随机整群抽样南宁市两个社区的671人为研究对象,分别于干预前、两年后、三年后,测量空腹血糖(FBG)、餐后2小时血糖(PBG)、空腹胰岛素(FINS)并计算HOMA稳态模型胰岛素抵抗指数(HOMAIR)、HOMA模型β细胞功能指数(HOMAβ)。结果两年后观察人群的FBG、PBG和HOMAIR比干预前有显著下降(P<0.01),而HOMAIR显著升高(P<0.01);观察三年后较干预前所有指标均显著下降(P<0.01),三年后较两年后FBG、PBG变化无显著性差异(P>0.05),而FINS、HOMAIR、HOMAIS下降仍具有显著性差异(P<0.01)。结论治疗性生活方式改变加药物对社区人群糖代谢产生显著的有益影响。
Objective Research on therapeutic lifestyle change plus medication of the community groups effect on abnormal glucose metabolism intervention. Methods We used a random cluster sampling of Nanning City in line with the two communities included in the standard 671 as an integrated intervention in the treatment of subjects,and measurement on fasting blood glucose(FBG),postprandial blood glucose 2 hours,fasting insulin and calculated the HOMA steady-state model of insulin resistance index(HOMAIR),Homa model β-cell function index (HOMAβ) on pre-interventionr,two years later,three years later. Results Two years later,the FBG,PBG,FINS and HOMAIR were more significantly decreased than those of pre-intervention (P〈0.01),and the HOMAIS was significantly increased (P〈0.01);and all the observation indicators decline significantly three years later (P〈0.01),compare three years later with two years later there was no significant difference on the FBG,PBG change (P〉0.05) ,however,the decline of FINS,HOMAIR,HOMAIS still has significant difference (P〈0.01). Conclusion Therapeutic lifestyle change plus medication on the community groups have a significant beneficial impact on glucose metabolism.
出处
《中国老年保健医学》
2009年第1期32-34,共3页
Chinese Journal of Geriatric Care
基金
广西科技攻关项目(桂科攻0472002-19)
中央保健专项资金科研课题(0627160)
国家自然科学基金(编号:30471926
30671110)
国家重点基础研究发展规划(973计划)项目(编号:2006CB503901)
国家人类遗传资源共享平台项目(编号:2006DKA21301)资助
关键词
干预
社区人群
生活方式
药物治疗
糖代谢
Intervention,community groups,way of life,drug therapy,glucose metabolism