热休克蛋白60抗体与冠心病的关系研究

A Study on Association between Antibody to Heat Shock Protein 60 and Risk of Coronary Heart Disease

[目的]探讨热休克蛋白60（HSP60）抗体水平与冠心病（CHD）的关系。[方法]采用病例．对照研究方法，选取未治疗过的CHD患者615例为病例组，以同性别、年龄（土1岁）进行1：1匹配，共选取615例无CHD且无重要脏器疾病者为对照组。采用间接酶联免疫吸附法测定血浆HSP60抗体水平，Logistic回归分析HSP60抗体与CHD的关系。[结果]CHD组的HSP60抗体水平明显高于对照组，差异有统计学意义（P=0．000）。在校正了传统的危险因素后，与下四分位数HSP60抗体组相比，上四分位数HSP60抗体组发生CHD的危险度是其2.48（95％CI：1．78～3．46）倍；多支病变的危险度是其3．60（95％CI：1．32．9．83）倍，差异有统计学意义。[结论]HSP60抗体与CHD的发病风险及其严重程度相关，提示HSP60抗体在CHD的发生发展中可能发挥某些作用。

[ Objective ] To investigate the relationship between the level of antibody to heat shock protein 60（ anti-HSP60 ） and risk, as well as severity of coronary heart disease（ CHD ）in Chinese population. [ Methods ] 615 CHD patients without treatment and 615 ageand sex-frequency matched controls were recruited in the case-control study. The level of anti-HSP60 in plasma were measured using enzyme-linked immunosorbent assay. Logistic regression model was used to analyze the relationship between anti-HSP60 level and CHD risk. [ Results ] The level of anti-HSP60 was significantly higher in CHD patients than in controls. Increasing level of anti-HSP60 was significantly associated with higher risk of CHD （ P for trend=1 × 10^-6 ） and with increasing severity of CHD as assessed by number of diseased vessels detected by angiography（ OR： 3.60; 95%CI： 1.32 to 9.83 ）. Multiple Logistic regression analysis results indicated these associations are independent of age, sex, and other risk factors. [ Conclusion ] Our data provide the exact evidence of a strong correlation between anti-HSP60 and CHD, suggesting that anti- HSP60 may play important roles during the development of CHD.