癫痫病人血浆和脑脊液中生长抑素含量及其临床意义

The concentration of somatostatin in plasma, CSF and its clinical significance in patients with epilepsy.

目的探讨癫痫病人血浆和ＣＳＦ中生长抑素（ＳＳ）的浓度及其临床意义。方法采用放射免疫法（ＲＩＡ）测定２７例癫痫病人和１２例正常对照组之血浆和ＣＳＦ样品。结果癫痫病人血浆和ＣＳＦ中ＳＳ浓度明显低于对照组。３天内有癫痫发作病人血浆和ＣＳＦ中ＳＳ浓度明显低于３天内无发作病人（Ｐ均＜００１）。

Objective To explore the concentration of somatostatin in plasma, cerebral spinal fluid (CSF) and its clinical significance in patients with epilepsy. Methods The concentrations of somatostatin plasma and CSF were detected by radioimmunoassay (RIA) in 27 cases of epilepsy and 12 subjects of control. Results Concentration of somatostatin in plasma (38.1±4.8 ng/L), CSF (76.8±7.5 ng/L) from patients with epilepsy were significantly lower than in plasma (67.4±6.6ng/L), CSF (198.8±12.4 ng/L) from control subjects. The concentration of somatostatin in plasma (26.3±3.8 ng/L) and CSF (51.0±5.7 ng/L) from epilepsy patients with seizures within three days were much lower, compared to the patients with no seizures (45.8±5.7 ng/L, 86.5±6.8 ng/L respectively, P<0.01). Conclusions Thechanges of somatostatin in plasma and CSF were highly associated with situation and development of epilepsy. 