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N末端脑钠肽原在心血管疾病诊治及预后中的应用进展 被引量：24

Application of N-terminal pro-B-type natriuretic peptide in diagnosis,treatment and prognosis of cardiovascular disease
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摘要 脑钠肽(BNP)是一种主要从心室分泌的多肽类激素,在心脏维持其结构和功能的正常中起着重要的代偿作用,其同源代谢产物N末端脑钠肽原(NT-proBNP)具有半衰期长、稳定性良好等优点,临床测定血浆NT-proBNP水平有助于呼吸困难的鉴别诊断,同时可用于对心血管疾病尤其是急慢性心力衰竭的疗效、预后评估及指导治疗。本文就NT-proBNP在心血管疾病尤其是充血性心力衰竭的诊断、治疗及预后中的应用作一综述。 Brain natriuretic peptide （BNP） is secreted by cardiomyocytes and plays an important role in the maintenance of cardiac structure and function. N-terminal pro-B-type natriuretic peptide （NT-proBNP） is the inactive metabolite of BNP, and it has a longer halftime and better stability than BNP. The detection of NT- proBNP plays an important role in the differential diagnosis of acute dyspnea, meanwhile, it can be used in the diagnosis, treatment and prognosis of cardiovascular diseases, especially in congestive heart failure. In this review, it focused on the clinical application of NT-proBNP in cardiovascular diseases.
作者 黄裕立 吴焱贤
机构地区 南方医科大学附属顺德第一人民医院
出处 《国际内科学杂志》 CAS 2009年第2期74-77,共4页 International Journal of Internal Medicine
关键词 N末端脑钠肽原 充血性心力衰竭 诊断 预后 NT-proBNP Congestive heart failure Diagnosis Proanosis
分类号 R541 [医药卫生—心血管疾病]
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参考文献25

  • 1Martinez-Rumayor A, Richards AM, Burnett JC, et al. Biology of the natriuretic peptides. Am J Cardiol, 2008,101 (3A) :3-8.
  • 2Azzazy HM, Christenson RH, Duh SH. Stability of B-type natriuretic peptide(BNP) in whole blood and plasma stored under different conditions when measured with the Biosite Triage or Beckman-Coulter Access systems. Clin Chim Acta. 2007. 384(1-2):176-178.
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  • 4Anwaruddin S, Lloyd-Jones DM, Baggish A, et at. Renal function, congestive heart failure, and amino-terminal probrain natriuretic peptide measurement:results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study. J Am Coil Cardiol, 2006, 47(1) :91-97.
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  • 6Januzzi JL, van Kimmenade R, Lainehbury J, et al. NTproBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure:an international pooled analysis of 1 256 patients:the International Collaborative of NTproBNP Study. Eur Heart J, 2006, 27 (3) :330-337.
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国际内科学杂志
2009年 第2期

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