摘要
Ghrelin可由胰岛α、β、ε细胞及胃黏膜细胞等分泌,可能通过旁分泌、自分泌或内分泌作用影响β细胞的分泌功能;同时抑制胰岛β细胞凋亡。Ghrelin呈剂量依赖性抑制葡萄糖刺激的胰岛素分泌,并呈瞬时调节,与胰岛素共同参与生理条件下的摄食和体重调节。1型糖尿病患者的Ghrelin基础水平偏高,经胰岛素治疗后下降,因此被认为是1型糖尿病初发及胰岛素治疗有效的标志物。Ghrelin水平与2型糖尿病的发病呈负相关;机体胰岛素抵抗时Ghrelin水平下降,胰岛素分泌增加,葡萄糖耐受性提高,是早期2型糖尿病的一种保护机制。
Ghrelin is produced and released from islet α、β、ε cells and gastric mucosal cells. It acts on islet cells via paracrine, autocrine or endocrine. Meantime, ghrelin can inhibit apoptosis of islet β cells. It has been demonstrated that ghrelin suppresses glucose-induced insulin release dose-dependendy and instantaneously. Ghrelin and insulin regulate food-intaking and body weight together. The fundamental ghrelin levels of type 1 diabetes patients are higher and can be decreased after insulin treatment, so it is a marker when type 1 diabetes is first diagnosed and a sign of cure efficiency. Decreased plasma levels of ghrelin are negatively correlated with the prevalence of type 2 diabetes. The action of ghrelin can be blocked by insulin resistance, and then the insulin secretion and glucose tolerance are increased.
出处
《国际内科学杂志》
CAS
2009年第2期89-92,共4页
International Journal of Internal Medicine
基金
广东省科学技术计划项目(2005B30701006)
