乳腺癌促红细胞生成素及其受体表达和肿瘤微血管生成关系研究

The correlation between the expression of Epo/Epo - R and MVD in patients with breast cancer

目的研究乳腺癌患者Epo／Epo—R表达及其与肿瘤血管生成的关系。方法对82例患者分别应用常规方法检测血红蛋白（Hb）值、用酶联免疫法检测血清Epo水平和应用免疫组化法检测Epo—R和肿瘤微血管密度（MVD），并进行相关分析。结果（1）82例肿瘤患者的Epo为（18．64±20．42）mU／ml，明显高于对照组的（8．10±4．96）mU／ml（P〈0．05）。Epo水平和Hb值之间相关分析r=-0．5259（P〈0．001）。（2）有贫血患者的Epo水平明显高于无贫血患者和对照组，而无贫血患者和对照组之间则无明显差异。（3）贫血和无贫血患者的Epo—R分别为（51．69±28．70）％和（43．47±19．84）％（P〉0．05）；贫血和无贫血患者的MVD分别为28．31±8．07和32．00±7．66（P〉0．05）。（4）Epo-R的表达与Epo水平和Hb值的高低无关；肿瘤血管的生成与Epo-R的表达和Epo水平、Hb值均不相关。结论乳腺癌患者的Epo水平明显增高，并与Hb值呈负相关；Epo-R和MVD的表达与患者有无贫血无关：肿瘤血管的生成与Epo-R的表达和Epo水平、Hb值均不相关。

Objective To study the correlation between the expression of erythropoietin （Epo）/ Epo - R and mi- crovessel density（MVD） in patients with breast cancer. Methods To test the hemoglobin （ Hb ） , serum Epo levels with ELISA and examine MVD with immuno - histochemistry for 82 patients with carcinoma. Results （ 1 ） The serum levels of Epo of 82 patients.with carcinoma were （ 18.64 ± 20.42 ） mU/ml, but control group were （ 8.10 ± 4.96 ） mU/ml （ P 〈 0. 05 ）.The correlation analysis was negative （ r = -0. 5259, P 〈0. 001 ）. （2）The Epo levels of patients with aneniia were higher than no - anemia patients and control group, but there were not significance between no - anemian patients and contfil group. （ 3 ） The Epo - R of patients with anemia and no - anemia were （ 51.69± 28.70） % and （43.47±19.84 ） % respectively （ P 〉0. 05 ） ; The MVD in patients with anemia and no - anemia were 28.31 ± 8.07 and 32.00± 7.66 （ P 〉 0. 05 ）. （4）The expression of Epo - R had not correlation with Epo levels and Hb levels,and MVD had not correlation with Epo - R, Epo levels and Hb levels. Conclusion The serum Epo levels of patients with breast cancer were higher and was negative cor- relation with Hb levels. The expression Epo - R and MVD had not correlation with Hb levels, there were not correlation between MVD and the Epo - R, Epo levels and Hb levels.