急性心肌梗死35例静脉溶栓前后QT离散度的变化

The changes of QT dispersion before and after thrombolytic therapy in 35 patients with acute myocardial infarction

目的：了解急性心肌梗死溶栓前后ＱＴ离散度的动态变化与溶栓疗效的关系。方法：回顾性地观察了溶栓、非溶栓患者治疗前后ＱＴ离散度的变化。结果：溶栓成功组（１２例）溶栓后２小时ＱＴ离散度明显增加，以后逐渐缩短。溶栓失败组（８例）溶栓后２小时、２天的ＱＴ离散度无明显变化。溶栓失败组和非溶栓组（１５例）治疗后７天～１４天的ＱＴ离散度较治前缩短，两组无明显差别。溶栓成功组７天～１４天的ＱＴ离散度较溶栓失败组明显缩短。结论：ＱＴ离散度的动态变化与静脉溶栓的疗效有关。

Objective:To assess the correlation between dynamic changes of QT dispersion(QTd) before or after thrombolytic therapy and the effect of thrombolytic therapy in acute myocardial infarction(AMI).Methods:20 patients with AMI treated with thrombolytic therapy and 15 patients with AMI treated with conventional therapy were retrospectively studied.Results:QTd in 12 patients with successful thrombolytic therapy increased remarkably in 2 h after treatment and then decreased gradually.However,no changes of QTd in 2 h and 2 d after therapy were found in 8 unsuccessful treated patients.After treatment QTd decreased in unsuccessful treated patients as well as in fifteen patients with conventional therapy,but no differences in QTd changes were found in these two groups QTd in 7～14 days after treament was significantly shorter in patients with successful thrombolytic therapy as compared with those unsuccessful treated subjects.Conclusion:There is a correlation between dynamic changes of QT dispersion and the effect of thrombolytic therapy in patients with AMI.