再生障碍性贫血18例血清甲状腺激素水平的变化

Study on the changes of serum thyrooxyindoles level in 18 patients with aplastic anemia

目的：探讨甲状腺素水平的变化与再生障碍性贫血（ＡＡ）的关系。方法：采用放射免疫法检测１８例ＡＡ患者甲状腺激素水平，并与正常人对照。结果：１８例ＡＡ患者的三碘甲状腺原氨酸（Ｔ３）、甲状腺素（Ｔ４）、游离三碘甲状腺原氨酸（ＦＴ３）、游离甲状腺素（ＦＴ４）水平均低于正常人，但促甲状腺素（ＴＳＨ）不升高，反三碘甲状腺原氨酸（ｒＴ３）不降低，且临床上ＡＡ患者均无甲状腺功能减低的症状和体征。结论：ＡＡ患者的Ｔ３、Ｔ４、ＦＴ３、ＦＴ４下降，不是真正的甲状腺功能减低，而可能是一种低甲状腺功能状态，属机体的一种代偿表现。

Objective:To probe into the relationship between the changes of serum levels of thyrooxyindoles level and aplastic anemia (AA).Methods:The serum levels of thyrooxyindoles were detected by radioimmunoassay in 18 patients with AA and compared with that of normal control subjects.Results:the levels of T3、T4、FT3 and FT4 in 18 patients were lower than that of the normal group,while TSH was not increased.The level of rT3 was not low in AA patients.All patients with AA didnt have any symptoms and signes of hypothyroidism,Conclusion:The reduced levels of T3、T4、FT3 and FT4 in AA patients do not really means hypothyroidism.Their changes in serum level may be indicators of decreased body function or decreased function of thyrooxyindoles.