轻度血管性认知损害患者血浆同型半胱氨酸浓度变化的临床研究

Changes of plasma total homocysteine concentrations in mild vascular cognitive impairment

目的探讨轻度血管性认知损害(mild vascular cognitive impairment,MVCI)与血浆同型半胱氨酸浓度间的关系。方法对46例MVCI患者及38例认知功能正常对照组的老年人进行血浆同型半胱氨酸(homocysteine,Hcy)测定,比较组间血浆Hcy浓度。结果MVCI组血浆总Hcy浓度(23.41±1.49μmol/L)显著高于对照组(17.01±2.48)μmol/L(t=14.61,P<0.001);结论增高的血浆Hcy浓度可能通过引起脑内小动脉硬化及神经细胞毒性作用而参与VMCI的患病。

Objective To explore the relationship between homocysteine （Hcy） concentrations and vascular mild cognitive impairment （MVCI）. Methods Plasma homoeysteine （Hcy） concentrations was measured in 46 patients with VMCI and in 38 controls with normal cognition. Results Hcy concentrations in patients with MVCI （23.41±1.491μmol/L）was significantly higher than that in controls （17.01±2.48μmol/L） （t=14.61, P〈0. 01）. Conclusions Hyperhomocysteine may play a role in the pathophysiology of MVCI by accelerating arteriolosclerosis and neurons toxicity.