摘要
目的:研究细辛挥发油的镇痛作用机制。方法:用水蒸气蒸馏法提取细辛挥发油成分,将其配制成不同剂量组,检测乙酸致痛小鼠脑组织和血清中NO、PGE2、MDA含量以及NOS和SOD活性。结果:细辛挥发油提取物能使乙酸致痛小鼠脑组织和血清中NO、PGE2、MDA含量及NOS活性明显降低,SOD活性明显增强。结论:细辛挥发油的镇痛作用机制可能与降低NO、PGE2、MDA含量及NOS活性,提高SOD活性有关。
Objective: To study the analgesic effects of asarum. Methods: Asarum volatile oil was obtained through steam distillation. Mice writhing response induced by ip 0.8 % acetic acid was adopted to observe the analgesia effect of asarum volatile oil. The content of nitricoxide (NO), prosraglandinE2 (PGE2) and malondialdehyde (MDA) and the activity of nitric-oxide Synthase (NOS) and su- peroxide dismu-tase (SOD) in the mice blood serum and brain tissue were detected. Results: The asarum volatile oil reduced the content of NO, PGE2 and MDA, inhibited the activity of NOS, and promoted the activity of SOD. Conclusion: The analgesic effects of asarum volatile oil may be related to the content of NO, PGE2 and MDA, and the activity of NOS and SOD.
出处
《现代生物医学进展》
CAS
2009年第4期718-720,共3页
Progress in Modern Biomedicine
关键词
细辛
挥发油
镇痛
Asarum
Volatile oil
Antalgic action