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巨噬细胞移动抑制因子信号转导机制及靶向治疗的研究进展 被引量：2

Progress on Signal Transduction Mechanism and Targeted Therapy of Macrophage Migration Inhibitory Factor
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摘要 巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)是一种多功能细胞因子,通过多种信号转导途径参与机体各种炎症性、自身免疫性疾病及肿瘤的发生与发展。本文综述了MIF的信号转导机制及基于MIF靶向治疗的最新研究进展。 Macrophage migration inhibitory factor （MIF）, a multifunctional cytokine, is involved in the development and progression of many inflammatory, autoimmune diseases and tumor through various signaling transduction pathways. In this paper, we reviewed the latest research progress of the signal transduction mechanism and the targeted therapy of MIF.
作者 谢娟 李国庆
机构地区 南华大学附属第二医院消化内科
出处 《现代生物医学进展》 CAS 2009年第4期752-754,720,共4页 Progress in Modern Biomedicine
关键词 巨噬细胞移动抑制因子 信号转导 靶向治疗 Macrophage migration inhibitory factor Signal transduction Targeted therapy
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学] Q813 [生物学—生物工程]
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参考文献21

  • 1Calandra T, Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity[J]. Nat Rev Immunol, 2003, 3(10): 791-800.
  • 2Leng L, Metz CN, Fang Y, et al. MIF signal transduction initiated by binding to CD74[J]. J Exp Med, 2003, 197(11): 1467-76.
  • 3Lue H, Kapurniotu A, Fingefle-Rowson G, et al. Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity[J]. Cell Signal, 2006, 18(5): 688-703.
  • 4Kleemann R, Hausser A, Geiger G, et al. Intracellular action of the cytokine MIF to modulate AP- 1 activity and the cell cycle through Jab 1 [J]. Nature, 2000,408(6809):2 ! 1-6.
  • 5Lue H, Thiele M, Franz J, et al. Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JABI in the control ofautocrine MIF activity[J]. Oncogene, 2007, 26(35):5046-59.
  • 6Daun JM, Cannon JG. Macrophage migration inhibitory factor antago- nizes hydrocortisone-induced increases in cytosolic IkappaB alpha[J]. Am J Physiol Regul Integr Comp Physiol, 2000, 279(3): R1043-9.
  • 7Petrenko O, Moll UM. Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway[J]. Mol Cell, 2005, 17(2): 225-36.
  • 8Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal tmnsduction pathway[J]. Cytokine, 2008,42(2): 145-51.
  • 9Roger T, Froidevaux C, Martin C, et al. Macrophage migration inhibitory factor (MIF) regulates host responses to endotoxin through modulationofToll-likereceptor4 (TLR4) [J].J Endotoxin Res, 2003,9 (2): 119-23.
  • 10Mitchell RA, Liao H, Chesney J, et al. Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response[J]. Proc Natl Acad Sci U S A, 2002, 99(1): 345-50.

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现代生物医学进展
2009年 第4期

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