摘要
MicroRNA(miRNA)是一类内源性、短小、大小为～22核苷酸的单链非编码RNA。miRNA广泛分布于真核细胞内,能够通过与靶mRNA3'末端非翻译区(3'-untranslated region,3'UTR)特异性结合来降解或抑制靶mRNA的翻译,从而对基因进行转录后基因表达的调控。miRNA不仅调控生物体的生长和发育过程,而且参与调控多种生理学和病理学过程,如细胞分化、细胞增殖、胰岛素的分泌、脂肪代谢以及肿瘤的形成。研究表明miRNA在肿瘤、糖尿病、代谢等多种疾病中发挥着重要的作用。本文对miRNA在脂肪细胞分化及脂类代谢中的调节作用进行综述。
MicroRNA （miRNA） is an endogenous single chain of non-coding RNA, which is approximately 22 nucleotides in length, miRNAs widely exist in eukaryotic cells and can degrade the target mRNA or inhibit the translation of target mRNA through binding to the 3＇ untranslated region（UTR） of the target mRNA. It is revealed that miRNAs not only regulate the growth and development process of organisms, but also regulate a variety of different physiological and pathological pathways such as cell differentiation, cell proliferation, insulin secretiom, fat metabolism and tumor formation. Studies showed that miRNAs play an important role in cancer, diabetes and metabolic diseases. In this review, we discussed remarkable advances about the regulation of miRNAs in adypocyte differentiation and lipid metabolism.
出处
《现代生物医学进展》
CAS
2009年第4期779-782,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(30670834)
