摘要
生长终止特异性同源盒基因(growth arrest-specific homeobox gene,Gax基因)是近年来发现的负性调控细胞增殖的一种转录因子。本文介绍Gax基因的发现和结构特征,详细阐述Gax抑制血管平滑肌细胞、血管内皮细胞及癌细胞增殖等生物学效应及其机制,展望Gax治疗疾病的潜在应用前景。
Gax gene is a newly found negative transcriptional regulator of cells proliferation. This paper intro- duces the detection and structural features of Gax, details the inhibitory effect of Gax on the proliferation of vascular smooth muscle cells, vascular endothelial cells and cancer cells, and explains the putative mechanisms therein in- volved. The potential for providing therapeutic insights into human diseases by modulating Gax activity is prospected.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2009年第1期206-210,共5页
Journal of Biomedical Engineering
关键词
GAX基因
细胞增殖
负性调控
Gax gene Cell proliferation Negative regulation