Gax基因对细胞增殖的负性调控及机制

Negative Regulation of Cells Proliferation by Gax Gene and Its Mechanisms

生长终止特异性同源盒基因(growth arrest-specific homeobox gene,Gax基因)是近年来发现的负性调控细胞增殖的一种转录因子。本文介绍Gax基因的发现和结构特征,详细阐述Gax抑制血管平滑肌细胞、血管内皮细胞及癌细胞增殖等生物学效应及其机制,展望Gax治疗疾病的潜在应用前景。

Gax gene is a newly found negative transcriptional regulator of cells proliferation. This paper intro- duces the detection and structural features of Gax, details the inhibitory effect of Gax on the proliferation of vascular smooth muscle cells, vascular endothelial cells and cancer cells, and explains the putative mechanisms therein in- volved. The potential for providing therapeutic insights into human diseases by modulating Gax activity is prospected.