关于针刺治疗脑缺血疾病机制中血管新生途径的新思路

A new idea on neovascularization approach in cerebral ischemia treated with acupuncture

在针刺治疗脑缺血疾病临床疗效机制的研究中,内皮祖细胞等存在于成体内的干细胞参与机体损伤修复的作用已成为当前组织工程研究的热点之一。资料显示,针刺可以从多种途径缓解和改善脑缺血带来的损伤且具有明显的治疗效果,而血管新生可能是其中的重要途径之一。缺血性损伤会导致内皮祖细胞参与血管新生修复,多种细胞因子在这一过程中发挥作用,它们可动员并诱导内皮祖细胞归巢。现有研究表明,针刺可以影响其中部分因子的表达,这种内在联系为针刺治疗脑缺血机制的认识开辟了新的思路。

In the study regarding therapeutic mechanism of cerebral ischemia treated by acupuncture, stem cells, such as endothelial progenitor cells （EPCs） participate in function damage-reparation, which has become the hotspot in tissue engineering research. The data demonstrated that acupuncture could release and ameliorate the injury caused by ischemia in many pathways; neovascularization may be an important one. When ischemia-injury occurred, EPCs take part in neovascularization, and many factors, which play a role in this process, can mobilize homing of EPCs. This study shows that acupuncture can influence the factors expression, which will provide new ideas for the research of acupuncture mechanism.