心包积液患者心包液中CGRP和内皮素水平与积液量和心功能有关

Study of CGRP and ET-1 in pericardiac fluid of patients with pericardiac effusion

目的探讨心包积液患者心包液中降钙素基因相关肽(CGRP)、内皮素(ET-1)与积液量、心功能的关系。方法35例心包积液患者按NYHA标准分为心功能Ⅲ、Ⅳ级,行超声心动图检查,计算积液量。行经皮穿刺心包腔内留置导管引流术时,取心包液及静脉血。正常对照组(血浆)30例。用放射免疫分析法测定心包液和血浆中CGRP、ET-1的浓度。结果心包液CGRP、ET-1的浓度显著高于血浆中的浓度(P<0.01),血浆中CGRP、ET-1含量较正常对照组明显升高(P<0.01),且心包液和血浆中CGRP、ET-1水平均与心功能相关(分别为P<0·01和P<0.05),心包液中CGRP、ET-1浓度与积液量呈正相关(分别为r=0.43、r=0.38,P<0.05)。结论心包积液患者心包液中CGRP、ET-1的浓度与心功能、积液量密切相关。

AIM To investigate the relationship between cardiac function, volume of pericardiac fluid （PF） and ET-1 and CGRP in the PF of patients with pericardiac effusion. METHODS The volume of PF was measured by echocariography in 35 patients with pericardiae effusion （NYHA class Ⅲ, Ⅳ）. ET-1 and CGRP levels in PF and serum were detected by RIA and compared with those in serum in 30 healthy subjects. RESULTS Both ET-1 and CGRP levels in PF were significantly higher than those in serum （P 〈0.01 ） in patients with pericardiac effusion and the serum ET-1 and CGRP levels in patents with pericardiac effusion were significantly higher than those in control group. ET-1 and CGRP levels in PF and serum were related to the cardiac function （P 〈0. 01, P 〈0. 05, respectively）. ET-1 and CGRP levels were positively related to the volume of PF （r =0.43, 0.38, respectively, P 〈0.05）. CONCLUSION ET-1 and CGRP levels in PF are closely related to the cardiac function and the volume of PF in patients with pericardiac effusion.