HIV／AIDS患者负性情绪及其与外周血T细胞计数关系的探讨

Relationship between psychological distress and T lymphocyte in HIV/AIDS patients

目的探讨HIV／AIDS患者负性情绪与外周血T淋巴细胞计数的相关性。方法采用症状自评量表（SCL-90）、抑郁自评量表（SDS）、焦虑自评量表（SAS）对102例HIV／AIDS患者进行问卷测评，进行外周血CD3^＋、CD4^＋、CD8^＋T细胞计数。CD4^＋T细胞〈0．2×10^9／L分为A组，≥0．2×10^9／L分为B组，分析A、B组负性情绪的差异性，CD4^＋细胞计数与SCL-90各项得分相关性，分别将CD3^＋、CD4^＋、CD8^＋T细胞计数作为因变量进行线形回归分析。结果77例（75．49％）HIV／AIDS患者存在程度不同的心理卫生问题，除敌对情绪外，躯体化、强迫、人际关系、抑郁、焦虑、恐怖、偏执、精神病性等八项因子分均较常模明显异常（P均〈0．05），抑郁和焦虑主观感受的发生率分别为67．65％（69／102）和43．13％（44/102），较正常人明显突出；A组患者的心理卫生问题、在抑郁、焦虑方面的主观感受较B组突出（P〈0．05）；CD4^＋T细胞数量与SCL-90总分及多项均分呈负相关，线性回归分析显示抑郁症状对CD3^＋、CD4^＋、CD8^＋T细胞的影响最大。结论大部分HIV／AIDS患者心理卫生状况存在明显异常，HIV／AIDS人群的情绪表达与CD4^＋T细胞计数有一定的相关性，以抑郁症状最明显。

Objective To explore the relationship between psychological distress and T lymphocyte counts in HIV/AIDS patients. Methods A total of 102 HIV/AIDS patients were measured by symptom check list（SCL- 90）, self-rating depressive scale （SDS） and self-rating anxiety scale（SAS）. Patients were divided into 2 groups based on CD4^＋ T lymphocyte counts 〈 0.2 × 10^9/L （group A） and ≥0.2 × 10^9/L（group B）.Results 77cases （75.49%） had psychological problems, including depression, relationship problems, psychosis, force etc. The prevalence of depression and anxiety were 67.65 % （69/102 ） and 43.13 % （44/102） respectively. The symptom of depression and anxiety of patients in group A were severer than those in group B （P 〈 0.05）. The CD4^＋T lymphocyte counts were significantly negatively correlated with the total score, depression score, paranoid score and psychosis score of SCL-90 （all P 〈 0.05 ）. Conclusion Most of the HIV/AIDS patients were in an obviously abnormal psychological status. The psychological distress symptom of HIV/AIDS patients might had negative effects on the number of CD4^＋ T lymphocyte.