摘要
目的探讨不同年龄系统性红斑狼疮(systemic lupus erythematosus,SLE)的临床特征。方法统计分析550例SLE患者(其中老年组102例,成年组415例,儿童组33例)的临床表现和实验室指标,并进行对照。结果老年组女∶男为5.38∶1,成年组女∶男为11.2∶1,儿童组女∶男为7.25∶1;发病到确诊的平均时间老年组长于成年组,儿童组比成年组明显缩短;老年组疲乏、关节痛、体重下降、肌痛肌无力、肺部病变多见。儿童组体重下降、肾损害、皮疹、神经精神症状多见。老年组血沉增快、肝功能损害多见,补体降低、dsDNA阳性率明显低于成年组(P<0.025)。儿童组U1RNP、dsDNA阳性率高,IgG升高、抗Sm阳性率低(P<0.05)。结论老年及儿童SLE的临床表现多不典型,易误诊和漏诊。老年SLE雷诺现象、脱发、肾损害发生率低,病情较轻,预后良好;儿童SLE肾脏损害,神经精神症状较多见,病情重、进展快,预后差。
Objective To investigate the clinical characteristics of systemic lupus erythematosus(SLE)with different ages. Methods Clinical manifestations and laboratory data of 550 patients (The late-onset group have 102, the adult onset group 415, the childhood-onset group 33) with SLE were collected and compared. Results The ratio of female to male was 5.38:1 in late-onset group and 11.2:1 in adult group,7.25:1 in ehildhood group respectively. The average time from onset to diagnosis in late-onset group was longer than that in adult group, shorter in childhoodonset group than that in adult group ( P 〈 0.025). The late-onset group had a higher prevalence of fatigue, arthritis, weight losing,muscular pain, weakness of muscle and pneumonopathy than adult group. The childhood group had a higher prevalence of weight losing, renal damage, neurologie disorder ( P 〈 0.025). The increase of ESR and liver damage in late-onset group were more happened,but low complements C3C4 and positive rates of anti-ds-DNA were less frequent(P 〈 0.025)in late-onset group compared with adult. The positive rates of anti-ds-DNA and U1RNP were more happened in childhood group, IgG increase, positive rates of anti-Sm were lower in childhood ( P 〈 0.025). Conclusion The clinical manifestations of late-onset and childhood-onset SLE are atypical, which can make a wrong diagnosis and missed diagnosis. Raynaud' s phenomenon, renal damage and neurologic disorder are less frequent in late-onset group, so the prognosis is favourable. The renal damage and neurologic disorder are often seen in childhood group and the status of illness in childhood group is serious.
出处
《宁夏医科大学学报》
2009年第1期62-64,67,共4页
Journal of Ningxia Medical University
基金
2008年宁夏自然科学基金资助项目(NZ0877)
关键词
系统性红斑狼疮
不同年龄
临床特征
systemic lupus erythematosns
different ages
clinical characteristics