期刊文献+

脂联素及其受体与大肠癌关系的研究进展 被引量:3

下载PDF
导出
摘要 大肠癌是临床常见的恶性肿瘤之一.随着生活方式及饮食习惯的改变,我国居民大肠癌发病率呈上升趋势。成为仅次于肺癌、胃癌的第三位恶性肿瘤。近年来肥胖被认为是乳腺癌、大肠癌等肿瘤的危险因素之一。目前人们对脂肪组织的认识发生了巨大的变化:脂肪组织不仅是能量的“贮存仓库”.而且也是一个重要的内分泌器官。
作者 胡志军 邹扬
出处 《实用医学杂志》 CAS 北大核心 2009年第4期507-509,共3页 The Journal of Practical Medicine
  • 相关文献

参考文献16

  • 1Waki H, Yamauchi T, Kamon J, et al. Impaired muhimerization of human adiponeetinmutants associated with diabetes. Molecular structure and muhimer formation of adiponectin [J]. Biol Chem, 2003, 278 (41 ) : 40352-40363.
  • 2Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects [J]. Nature, 2003,423 (6941 ) : 762-769.
  • 3Otake S, Takeda H, Suzuki Y, et al. Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma: evidence for participation of insulin resistance [J]. Clin Cancer Res, 2005 , 11 (10) : 3642-3646.
  • 4Wei E K, Giovannucci E, Fuchsc S, et al. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study [J]. J Natl Cancer Inst, 2005,97(22) : 1688-1694.
  • 5Fujisawa T, Endo H, Tomimoto A, et al. Adiponectin suppresses colorectal carci-nogenesis under the high-fat diet condition [J ]. Gut, 2008,57( 11 ) : 1531-1538.
  • 6Yoneda K, Tomimoto A, Endo H, et al. Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue [J]. Oncol Rep, 2008,20 (3) :479-483.
  • 7Williams C J, Mitsiades N, Sozopoulos E ,et al. Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors [J]. Endocrine Related Cancer, 2008,15( 1 ) :289-299.
  • 8Sekharam M, Zhao H, Sun M, et al. Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway [J]. Cancer Res, 2003,63(22) :7708-7716.
  • 9Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acidoxidation by activating AMT-activated protein kinaao [J ]. Nat Med, 2002,8 ( 11 ) : 1288- 1295.
  • 10Bub J D, Miyazaki T, Iwamoto Y. Adiponectin as a growth inhibitor in prostate cancer cells [J]. Biochem Biophys Res Commun, 2006, 340(4) : 1158-1166.

同被引文献38

  • 1高蕾,白岚,南清振,杨希山,张亚历,陈凯,温汉平.Investigation of tumor necrosis factor receptor -p55expression in human colorectal cancer[J].Journal of Medical Colleges of PLA(China),2001,16(4):285-287. 被引量:5
  • 2NAWATA K,ISHIDA H,UENISHI K,et al.The relationship between serum leptin concentration and the percentage of body fat in Japanese high school students[J].Asia Pac J Public Health,2008,20(3):180-188.
  • 3CZITO BG,WILLETT CG.Thirty years of rectal cancer research:a brief history[J].Oncology,2008,22(12):1441-1444.
  • 4Wang Y,Lam KS,Xu JY,et al.Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner[J].J Biol Chem,2005,280(18):18341-18347.
  • 5Smith MR,Lee H,Nathan DM.Insulin sensitivity during combined androgen blockade for prostate cancer[J].J Clin Endocrinol Metab,2006,91(4):1305-1308.
  • 6Ouchi N,Kihara S,Arita Y,et al.Novel modulator for endothelial adhesion molecules:adipocyte-derived plasma protein adiponectin[J].Circulation,1999,100(25):2473-2476.
  • 7Van Gaal LF,Mertens IL,De Block CE.Mechanisms linking obesity with cardiovascular disease[J].Nature,2006,444(7121):875-880.
  • 8Scherer PE,Williams S,Fogliano M,et al.A novel serum protein similar to C1q,produced exclusively in adipocytes[J].J Biol Chem,1995,270(45):26746-26749.
  • 9Maeda K,Okubo K,Shimomura I,et al.cDNA cloning and expression of a novel adipose specific collagen-like factor,apM1(AdiPose Most abundant Gene transcript 1)[J].Biochem Biophys Res Commun,1996,221(2):286-289.
  • 10Arita Y,Kihara S,Ouchi N,et al.Paradoxical decrease of an adipose-specific protein,adiponectin,in obesity[J].Biochem Biophys Res Commun,1999,257(1):79-83.

引证文献3

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部