对非酒精性脂肪肝患者生活方式结合膳食干预的效果观察

EFFECT OF LIFE STYLE COMBINED WITH DIETARY INTERVENTION ON NON-ALCOHOLIC FATTY LIVER DISEASE

目的探讨改变生活方式和饮食干预对非酒精性脂肪肝(NAFL)的治疗效果。方法从2006～2007两年间来我院健康查体管理中心某机关查体人员中筛选出NAFLD 125例,年龄在30～60岁。其中,经B超诊断轻度脂肪肝48例,中度70例,重度7例,自愿接受饮食及运动治疗干预作为观察对象。采取询问法记录患者干预前和干预后3 d摄入食物的种类和数量及日常生活习惯。制定膳食干预原则,编制食谱,给予饮食和运动指导,共12个月,并定期随访。结果通过12个月的干预,观察对象的体重(BW)、体质指数(BMI)、腰臀比(WHR)及血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和丙氨酸转氨酶(ALT)与干预前比较均有显著性下降。高密度脂蛋白胆固醇(HDL-C)没有改变。B超检查,16%恢复正常,中、重度脂肪肝患者由原来的77人降至31人,下降了59.7%。结论合理的饮食干预结合适当的有氧运动,对于脂肪肝具有良好的治疗作用。

Objective To investigate the effect of life style combined with dietary intervention on non-alcoholic fatty liver disease（NAFLD）.Method One hundred and twenty five subjects of NAFLD with overweight and obesity,aged 30-60 years,were enrolled in the study from the group for physical examination in Health Administration Center of our hospital during 2006-2007.They were diagnosed to be 48 mild,70 moderate and 7 severe cases by ultrasonic tomography.A regime of dietary intervention combined with exercise was planned according to 3 d dietary survey before intervention.They were asked to follow the therapeutic menus and exercise instruction during 12 mon of the study.We followed up the subjects and gave them instructions regularly in the whole period of study.Results After 12 mon interven-tion,the body weight（BW）,body mass index（BMI）,waist-hip ratio（WHR）,serum total cholesterol（TC）,triglycerides（TG）,low-density lipoprotein cholesterol（LDL-C） and alanine glutamate aminotransferase（ALT） of the subjects were decreased significantly.High density lipoprotein cholesterol（HDL-C） was not changed.By ultrasonic tomography,16% of the subjects recovered to normal,and 77 moderate to severe cases deceased to 31,with reduction rate 59.7%.Conclusion Good therapeutic effects were observed after 12 mon of dietary intervention combined with rational exercise.