期刊文献+

阿托伐他汀治疗慢性心力衰竭30例 被引量:3

下载PDF
导出
摘要 目的:观察阿托伐他汀治疗慢性心力衰竭的临床疗效。方法:将60例慢性心力衰竭患者分为治疗组(30例)和对照组(30例)。对照组接受常规抗心力衰竭治疗,治疗组在常规基础上加用阿托伐他汀(20mg/d),共治疗6个月。治疗前后进行疗效观察及用超声心动图检查心功能参数的变化。结果:治疗组和对照组临床疗效总有效率为90%和80%,但差异无显著性(P>0.05)。治疗组心功能参数(左心室舒张末径、左心室心缩末径、左心室射血分数)改变较对照组明显(P<0.05)。结论:阿托伐他汀短期治疗慢性心力衰竭有良好作用,且能明显改善心功能。
出处 《实用医学杂志》 CAS 北大核心 2009年第4期635-637,共3页 The Journal of Practical Medicine
  • 相关文献

参考文献12

  • 1Krum H, Latini R, Maggioni A P, et al. Statins and symptomatic chronic systolic heart failure: a post-hoc analysis of 5010 patients enrolled in Val-HeFT [J]. Int J Cardial, 2007, 119( 1 ):48-53.
  • 2Go A S, Lee W Y, Yang J, et al. Statin therapy and risks for death and hospitalization in chronic heart failure [J]. JAMA, 2006,296 (17) :2105-2111.
  • 3Delbosc S, Cristol J P, Descomps B, et al. Simvastatin prevents angiotensin Ⅱ-induced cardiac alteration and oxidative stress [J]. Hypertension, 2002,40(2) : 142-147.
  • 4Pliquett R U, Cornish K G, Peuler J D, et al. Simvastatin normalizes autonomic neural control in experimental heart failure [J]. Circulation, 2003,107(19) :2493-2498.
  • 5Bauersachs J, Galuppo P, Fraccarollo D, et al. Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme a reductase inhibition.with cerivastatin in rats with heart failure after myocardial infarction [J]. Circulation, 2001,104(9) : 982-985.
  • 6Dichtl W, Dulak J, Frick M, et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells [J]. Arterioscler Thromb Vasc Biol, 2003,23(1):58- 63.
  • 7Landmesser U, Engberding N, Bahlmann F H, et al. Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase [J]. Circulation, 2004, 110(14) : 1933-1939.
  • 8Laufs U, Fata V L, Liao J K. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase [J]. J Biol Chem, 1997,272(50) :31725-31729.
  • 9Landmesser U, Bahlmann F, Mueller M, et al. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans [ J ]. Circulation, 2005,111 (18) : 2356-2363.
  • 10Hasegawa H, Yanlamoto R, Takano H, et al. 3-Hydroxy-3- methylglutaryl coenzyme A reductase inhibitors prevent the development of cardiac hypertrophy and heart failure in rats [J]. J Mol Cell Cardiol, 2003,35(8) :953-960.

同被引文献21

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部