摘要
2%的明矾注射液对氰化物中毒具有很好的治疗和解救作用,但是在家兔体内药物动力学研究未见报道。本研究证明在试验条件下明矾在家兔体内的消除半衰期(t1/2)为(2.6797±0.6042)h,体清除率(CLB)为(0.5026±0.0116)dL/(kg.h),表观分布容积(Vd)为(1.9452±0.3371)dL/kg,说明明矾注射液代谢较快,在家兔体内分布范围窄。临床用于治疗动物氰化物中毒时,宜反复给药,直至症状消失为止。
The 2% alum injection has good treatment and rescue action for poisoning of cyanide, but the pharmacokinetics of it has not been reported. This studies proved that the half life （t1/2）was （2. 6797±0. 6042）h, body clearance was （0. 5026±0. 0116） dL/（kg. h） and pparent volume of distri- bution was （1. 9452 ±0. 3371）dL/kg. It was indicated that the alum injection metabolized quickly and distribution was narrow in the rabbit body. It shoud administe repeatedly until symptoms disappeared in clinical treatment of animals poisoning of cyanide.
出处
《西北农业学报》
CAS
CSCD
北大核心
2009年第1期41-44,共4页
Acta Agriculturae Boreali-occidentalis Sinica
基金
教育部高校科技创新工程培养基金
