电针阳陵泉、脾俞穴对重症肌无力模型大鼠神经肌肉接头传递的影响

Effects of Electroacupuncture at Yanglingquan ( GB34 ) and Pishu( BL2 0 ) Points on Transmission of Neuromuscular Junction in Rats of Myasthenia Gravis

以乙酰胆碱电位 (Ach P)、小终板电位 (MEPP)及血清抗乙酰胆碱受体抗体 (Ach RAb)滴度为观察指标 ,探讨了电针“阳陵泉”、“脾俞”穴对重症肌无力模型大鼠神经肌肉接头传递过程的影响及其作用机制。结果表明 ,电针“阳陵泉”穴或“脾俞”穴均能使重症肌无力 (MG)大鼠的 Ach P与MEPP振幅升高 ,但对 Ach P时程、MEPP的频率及血清 Ach RAb滴度却没有明显影响 ;同时电针“阳陵泉”、“脾俞”二穴 ,则使 MG大鼠的 Ach P、MEPP振幅升高更加显著 ;电针穴位临近肌肉则没有如此效应。提示 ,电针“阳陵泉”、“脾俞”穴有提高 MG大鼠神经肌肉接头传递的作用。

Effects of electroacupuncture at Yanglingquan and Pishu points on transmission of neuromuscular junc- tion in rats of myasthenia gravis( MG) and their mech- anisms were studied using acetylcholine potential ( ACh P) ,minor end- plate potential( MEPP) and titer of serum acetylcholine receptor antibody( ACh RAb) as in- dexes.Results showed that electroacupuncture of Yan- glingquan or Pishu point could increase the amplitude of ACh P and MEPP,but did not influence the time course of ACh P,frequency of MEPP and the titer of serum Ach RAb in the rats of MG;Electroacupuncture of both Yanglingquan and Pishu points could increase more obviously the amplitute of ACh P and MEPP in the rat;electroacupuncture on close muscle did not have the effects.It is suggested that elec- troacupunctrure of Yanglingquan and Pishu points can increase transmission of neuromuscular junction in the rat of MG.