分化性甲状腺癌组织中P-糖蛋白表达及临床意义

CLINICAL SIGNIFICANCE OF P-GLYCOPROTEIN EXPRESSION IN DIFFERENTIATED THYROID CARCINOMA

目的探讨Ｐ┐糖蛋白在分化性甲状腺癌组织中表达及临床意义。方法采用免疫组织化学法对６６例分化性甲状腺癌，３７例甲状腺良性病变组织行Ｐ┐糖蛋白测定，作相关临床因素分析。结果分化性甲状腺癌组织中Ｐ┐糖蛋白的阳性表达率为５７．５％。甲状腺良性病变表达率仅２１．６％。伴有淋巴结转移的甲状腺癌Ｐ┐糖蛋白表达率为８０．６％，无淋巴结转移者为３７．１％。Ｐ┐糖蛋白的表达与年龄、性别，病理类型无明显相关。结论分化性甲状腺癌是一种具有先天性Ｐ┐糖蛋白高表达疾病。

bjective:To study the clinical significance of Pglycoprotein(Pgp)expression in differentiated thyroid carcinoma.Methods:The expression of Pgp was studied immunohistochemically in 66 thyroid carcinoma specimens, and compared with 37 thyroid benign diseases.Results:The positive rate of Pgp expression in carcinoma group was 576%, but only 21.6% in benign group (P<001);the positive rate in carcinoma with metastatic lymph nodes was 80.6%, only 37.1% in no metastasis(P<005).There was no significant correlation between expression of Pgp and age,sex,nor phathological types.Conclusion:Differentiated thyroid carcinoma is the disease with high expression rate of Pgp