胺碘酮联合美托洛尔治疗急性心肌梗死伴快速房颤的临床疗效

Amiodarone combined metoprolol in the treatment of acute myocardial infarction Atrial fibrillation with rapid clinical efficacy

目的:观察胺碘酮联合美托洛尔(倍他乐克)治疗急性心肌梗死(AMI)伴快速房颤的临床疗效。方法:60例AMI患者伴快速房颤,给予胺碘酮首剂150mg静脉推注,15min后未转复窦性心律,可再给以150mg静推,继之0.5～1.0mg·min-1持续静滴1～3d,静脉用药同时给予口服胺碘酮(第1周200mg,tid,第2周200mg,bid,第3周200mg,qd,24h总量<1200mg)和倍他乐克(25～50mg,bid),观察用药前后房颤转复、心率、血压变化情况。结果:55例房颤转复,所有患者心室率得到控制,用药前后血压平稳。结论:胺碘酮联合美托洛尔治疗急性心肌梗死伴快速房颤安全有效。

OBJECTIVE To observe the effect of miodarone combined with metoprolol on the treatment of acute myocardial infarction with rapid atrial fibrillation clinical efficacy. METHODS 60 cases of patients with AMI recently occurred in rapid at rial fibrillation, amiodarone for the first 150 mg dose intravenous injection, after 15 min not to resume sinus rhythm, gave 150 mg more, followed by 0. 5 to 1. 0 mg·min^-1 continuous intravenous infusion for 1 - 3 d, intravenous drug use at the same time to give oral amiodarone（in the first week of 200 mg, 3 times·d^-1, the first 2 weeks 200 rng, 2 times·d^-1, the first 3 weeks 200 mg, 1 time·d^-1, 24 h total〈1 200 mg） and metoprolol （25 - 50 mg, 2 times·d^-1）, atrial fibrillation before and after treatment to rehabilitation, heart rate, blood pressure change were observed. RESULTS 55 cases of atrial fibrillation were rehabilitated, all patients with ventricular rate were controlled, blood pressure became normal. CONCLUSION Amiodarone combined with metoprolol in the treatment of acute myocardial infarction with rapid atrial fibrillation is safe and effective.