依达拉奉对放射性脑水肿的影响

Effect of edaravone on radioactive brain edema

目的:观察依达拉奉对放射性脑水肿的影响。方法:选择98例放射性脑水肿患者,随机分成治疗组50例和对照组48例,对照组给予20%甘露醇250mL静滴(q12h),地塞米松磷酸钠注射液10mg加入10%葡萄糖注射液500mL静滴(qd),疗程14d;治疗组在对照组治疗的基础上给予依达拉奉注射液30mg加入生理盐水注射液100mL静滴(bid),疗程14d。2组在治疗后均做脑部CT或MRI检查,按照脑部CT或MRI显示脑水肿最大层面的长×宽测算脑水肿的面积,以脑水肿的面积表示脑水肿的程度,观察脑水肿的变化。结果:治疗组的总有效率是92%,对照组的总有效率是65%,治疗组的总有效率明显优于对照组(P<0.01),2组均无明显不良反应。结论:依达拉奉可以减轻放射性脑水肿,且临床应用安全。

OBJECTIVE To observe effect of edaravone on radioactive brain edema. METHODS 98 patients with radioactive brain edema were chosen and divided into treatment group of 50 cases and control group of 48 cases randomly, the patients in control group received 20% mannitol 250 mL, iv, drip, q12h,dexamethasone injection 10mg dissolved in 10% glucose injection 500 mL, iv, drip, qd,for 14 day; the patients in treatment group received control treatment and received edaravone injection 30mg dissolved in sodium chloride injection 100 mL, iv, drip, bid, for 14 day. Head CT or MRI in two groups were checked after treatment, counted brain edema area according to long multiplication wide in maximum area of head CT or MRI showed brain edema, observed changes of brain edema according to area changes. RESULTS the total active rat in treatment group was 92%, the total active rat in control group was 65%, the total active rat in treatment group was better than in control group（P 〈0. 01 ）, adverse reaction was not obvious in two groups. CONCLUSION Edaravone injection can lighten radioactive brain edema, and edaravone is safe in the treatment of radioactive brain edema.