玉郎伞多糖对小鼠急性酒精性肝损伤保护作用的研究

Protective Effect of Yulangsan Polysaccharide on Acute Alcohol Hepatic Injury in Mice

目的:研究玉郎伞多糖对小鼠急性酒精性肝损伤的保护作用。方法:小鼠ig10mL·kg-150%酒精,建立急性酒精性肝损伤模型;测定血清转氨酶、肝组织超氧化物歧化酶活性及甘油三酯含量,并进行病理组织学观察。结果:各剂量玉郎伞多糖能显著降低小鼠血清转氨酶活性和甘油三酯含量,显著提高肝组织超氧化物歧化酶活性,减少肝细胞脂滴数量;高、中剂量玉郎伞多糖可显著减轻酒精性肝损伤小鼠肝细胞的脂肪变性。结论:玉郎伞多糖可减轻酒精对脂肪代谢的影响,对急性酒精性肝损伤有保护作用。

OBJECTIVE： To study the protective effect of Yulangsan polysaccharide（YLSPS） on acute alcoholic hepatic injury in mice.METHODS： 50% alcohol at a dose of 10 mL · kg^-1 was administered （ig） to mice to establish acute alcoholic hepatic iniury model .The activities of serum transaminase and superoxide dismutase（SOD） and the triglyeride（TGL） level were determined and a pathohistological study was performed. RESULTS： The activity of serum transaminase and the content of triglyceride in mice were significantly down- regulated by different doses of YLSPS, but the activity of superoxide dismutase in YLSPS- treated groups was significantly up - regulated and the number of fat droplets was reduced. Fatty degeneration in acute alcoholic hepatic injury model mice was significantly abated by high- dose and middle- dose YLSPS.CONCLUSION： The protective effect of YLSPS on alcohol- induced acute hepatic injury in mice was attributed to its action in lessening the effect of alcohol on lipometabolism.