我国2000～2008年中药不良反应文献综合分析

Aggregate Analysis on Literature of ADRs Induced by Chinese Materia Medica During 2000～2008

目的:分析中药制剂所致药品不良反应发生的情况。方法:对100种杂志刊登的933例中药制剂所致不良反应进行分析。结果:共涉及中药制剂156种,给药途径5种,其中静脉给药方式不良反应发生率最高,达78.46%。不良反应中以全身性反应发生率最高,达57.77%。结论:应加强有关中药安全用药知识的普及、规范临床合理应用中药及其制剂,实施对中药不良反应的监测和干预。

OBJECTIVE： ,To probe into the condition of the occurrence of the adverse drug reaetions（ADRs） induced by Chinese materia medica.METHODS： A total of 933 ADR cases induced by Chinese materia medica published in 100 different kinds of journals during 2000-2008 were studied retrospectively.RESULTS： A total of 156 kinds of Chinese materia medica were involved in these ADRs, which were administered by 5 routes, with intravenous administration showing the highest incidence at 78.46%. Among all the ADRs, the systemic reactions represented 57.77% .CONCLUSION： It is necessary to popularize the knowledge on safe medication of Chinese materia medica,standardize clinical rational use of Chinese materia medica and its preparations and tighten control and monitoring on the ADRs induced by Chinese materia medica.