颈动脉内膜中层厚度和血清胆红素水平的关系

Clinical Study on the Relationship of Serum Bilirubin and Carotid Intima-Media Thickness in Patients with Transient Ischemic Attack.

目的观察血清胆红素水平变化与颈动脉内膜中层厚度的关系。方法选择短暂性脑缺血患者130例,按颈动脉超声检测结果分内膜正常组、内膜损害组,测定二组患者的血清胆红素水平,并进行统计学分析。结果内膜损害组血清胆红素较内膜正常组显著为低,差异有显著性(P<0.01)。Logistic多元回归分析发展,血清胆红素为TIA患者颈动脉内膜损害的独立危险因素,血清胆红素水平与颈动脉内膜厚度呈负相关。结论血清胆红素水平变化与动脉内膜中层厚度关系密切,低胆红素水平是动脉粥样硬化重要的危险因素。

Objective To explore the relationship between serum bilirubin and carotid intima-media thickness（IMT） in patients with transient ischemic attack（TIA）. Methods 130 patients with TIA whose carotid IMT were detected by ultrasound were divided into normal IMT group and intima impaired group. Their serum bilimbin levels were measured and compared. Results The level of serum bilimbin in intima impaired group was significantly lower than that in normal IMT group（ P 〈 0.01）. The result of logistic regression analysis indicated that sermn bilirubin was one of the independent risk factors for carotid intima lesion. Low senma bilirubin level was related to increased carotid IMT. Conclusions Serum bilirubin is closely related to the carotid IMT. Lower serum bilirubin concentration might be an important risk factor of athemsclerosis.