摘要
用开搏通对24例老年糖尿病肾病患者进行治疗,同时设立对照组23例。经过21d的治疗后发现开搏通治疗组患者血浆血管紧张素Ⅱ和尿蛋白排出率明显下降(P<001,P<005),尿6酮前列腺素F1α显著升高(P<005),而对照组上述指标无显著变化(P>005);部分患者血浆肾素活性正常或低于正常,而尿中前列腺素代谢产物增多。因此推论开搏通通过减少血管紧张素Ⅱ使血压下降,改善了肾功能,同时由于血管紧张素Ⅱ的减少,优先扩张出球小动脉,改善了肾内血流动力学的异常状态;开搏通还可能通过激肽释放酶激肽前列腺素系统参与对肾脏血流动力学的调节而改善肾功能。
お?4 cases of old patients with diabetic renopathy were sudied in the experiment using Captopril, and 23 cases were in control group. After 21 days, it shows significant decrease of angiotensin Ⅱ and ejectionrate rate of urinary protein(P<001,P<005), and shows significant in crease in 6ketoprostaglendin F1α(P<005). There is no significant changes in control group. The another calculated that Captopril can decrease angiotensin Ⅱ and blood pressure. Then renal function goes better. The decrease of angiotensin Ⅱ deminant dilate the efferent glomerulus arteriole and improve the abnormal state of hemodynamics of kidney. We also found plasma renin activity is normal or below normal value in part of the patients. And the metabolic product of prostaglandin increase. Then we guess Captopril also regulate the hemodynamics through killikreinprostaglandin system and improve the renal function.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1998年第2期80-82,共3页
Chinese Journal of Gerontology